Drug ClassPyrimidine synthesis inhibitor (DMARD; dihydroorotate dehydrogenase inhibitor)
PrescriptionRequired (Rx)
Habit FormingNo
Overview
Distributor inventory | Tablet
Uses & Benefits
Treatment of active rheumatoid arthritis; may also be used in psoriatic arthritis as prescribed.
How It Works
Leflunomide is a disease-modifying antirheumatic drug (DMARD). Its active metabolite inhibits dihydroorotate dehydrogenase, reducing pyrimidine synthesis and thereby suppressing proliferation and activity of activated T-lymphocytes, which decreases joint inflammation and damage.
Directions for Use
Tablet for oral use. Take exactly as prescribed, usually once daily, with or without food, preferably at the same time each day. Do not stop abruptly without medical advice; regular blood tests are required during treatment.
Not recommended in pregnancy; causes severe birth defects—effective contraception is required during treatment and until drug is eliminated (may require cholestyramine/activated charcoal washout). Avoid breastfeeding. Risk of serious liver injury—do not use in severe hepatic impairment; avoid alcohol; monitor LFTs. Can cause bone marrow suppression/infections—monitor CBC; avoid live vaccines. Use caution in hypertension and lung disease (rare interstitial lung disease). Discuss washout before planned pregnancy (women and men) or before switching to another hepatotoxic/immunosuppressive drug.
Drug Interactions
Manufacturer
BRINTON PHARMACEUTICALS
BrandBrinton Pharmaceuticals Pvt Ltd
Methotrexate and other hepatotoxic drugs (increased liver toxicity), warfarin (may alter INR), rifampicin (may increase active metabolite levels), cholestyramine/activated charcoal (markedly decreases levels; used for washout), live vaccines (reduced response/infection risk), other immunosuppressants (additive infection risk)
Storage Instructions
Store below 25°C in a dry place, protected from moisture and light. Keep in original pack and out of reach of children.
Leflunomide is a disease-modifying antirheumatic drug (DMARD). Its active metabolite inhibits dihydroorotate dehydrogenase, reducing pyrimidine synthesis and thereby suppressing proliferation and activity of activated T-lymphocytes, which decreases joint inflammation and damage.
How should I use this medicine?
Tablet for oral use. Take exactly as prescribed, usually once daily, with or without food, preferably at the same time each day. Do not stop abruptly without medical advice; regular blood tests are required during treatment.
How should I store this medicine?
Store below 25°C in a dry place, protected from moisture and light. Keep in original pack and out of reach of children.
Do I need a prescription for this product?
Yes, this product requires a valid prescription (Rx). Upload it during checkout when prompted.
Can prices or availability change?
Yes. Prices and availability can change based on inventory and serviceability. The latest details are shown at checkout.
How do I place an order?
Select a variant, add to cart, enter delivery address, upload prescription if required, and pay securely.
Manufacturer & Brand
Brand:Brinton Pharmaceuticals Pvt Ltd
Manufacturer:BRINTON PHARMACEUTICALS
HSN Code:30049099
Alternatives
Alternatives are suggested by pharmacists after reviewing your order and prescription.
Disclaimer: Product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalized guidance.
Sources: Manufacturer labeling, established medical literature (DMARD/leflunomide monographs), CDSCO/Indian regulatory labeling standards
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