Lefupro 20 mg Tablet

Lefupro 20 mg Tablet contains Leflunomide 20 mg. Prescription required.

Treatment of active rheumatoid arthritis; may also be used in psoriatic arthritis as prescribed.

Leflunomide is a disease-modifying antirheumatic drug (DMARD). Its active metabolite inhibits dihydroorotate dehydrogenase, reducing pyrimidine synthesis and thereby suppressing proliferation and activity of activated T-lymphocytes, which decreases joint inflammation and damage.

Tablet for oral use. Take exactly as prescribed, usually once daily, with or without food, preferably at the same time each day. Do not stop abruptly without medical advice; regular blood tests are required during treatment.

Diarrhoea, nausea, abdominal pain, headache, dizziness, rash, hair thinning/alopecia, elevated liver enzymes, hypertension, respiratory infections

Not recommended in pregnancy; causes severe birth defects—effective contraception is required during treatment and until drug is eliminated (may require cholestyramine/activated charcoal washout). Avoid breastfeeding. Risk of serious liver injury—do not use in severe hepatic impairment; avoid alcohol; monitor LFTs. Can cause bone marrow suppression/infections—monitor CBC; avoid live vaccines. Use caution in hypertension and lung disease (rare interstitial lung disease). Discuss washout before planned pregnancy (women and men) or before switching to another hepatotoxic/immunosuppressive drug.

Methotrexate and other hepatotoxic drugs (increased liver toxicity), warfarin (may alter INR), rifampicin (may increase active metabolite levels), cholestyramine/activated charcoal (markedly decreases levels; used for washout), live vaccines (reduced response/infection risk), other immunosuppressants (additive infection risk)

Store below 25°C in a dry place, protected from moisture and light. Keep in original pack and out of reach of children.

Lefra 20 Tablet, Lefumide 20 Tablet, Lefno 20 Tablet, Lefumide 20 mg Tablet, Lefumide 20 (Leflunomide) Tablet