Macorate CR 500MG Tab

Tablet

Treatment of epilepsy/seizure disorders (partial and generalized seizures), prevention of migraine (as prescribed), management of manic episodes in bipolar disorder (as prescribed)

Sodium valproate increases levels of the inhibitory neurotransmitter GABA in the brain and reduces abnormal neuronal firing. This helps stabilize electrical activity and prevents seizures/mood swings.

Swallow the controlled-release tablet whole with water; do not crush or chew. Take at the same time each day, preferably with food to reduce stomach upset. Dose and duration are as prescribed; do not stop abruptly without medical advice.

Nausea, vomiting, stomach pain, diarrhoea, dizziness, drowsiness, tremor, weight gain, hair loss, increased appetite, headache

Risk of severe liver injury and pancreatitis—seek urgent care for severe abdominal pain, persistent vomiting, jaundice, dark urine or unusual tiredness. Can cause birth defects and developmental disorders; avoid in pregnancy unless clearly needed and under specialist advice. Monitor liver function and blood counts as advised; caution in patients with liver disease, bleeding disorders, or history of pancreatitis. May cause drowsiness—avoid driving/operating machinery if affected. Do not stop suddenly; may worsen seizures.

Other antiepileptics (phenytoin, carbamazepine, phenobarbital, lamotrigine, topiramate), aspirin/salicylates, warfarin and other anticoagulants/antiplatelets, CNS depressants (benzodiazepines, opioids, alcohol), rifampicin, erythromycin, carbapenem antibiotics (e.g., meropenem) which can markedly reduce valproate levels

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Valparin CR 500 Tablet, Encorate Chrono 500 Tablet, Valprol CR 500 Tablet, Epival CR 500 Tablet, Divalproex ER 500 Tablet