Simbrinza Drops

Simbrinza Drops contains Brinzolamide 1% w/v + Brimonidine tartrate 0.2% w/v ophthalmic suspension and is used for elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension. Prescription required.

Treatment of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension

Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humour production in the eye, lowering intraocular pressure. Brimonidine is an alpha-2 adrenergic agonist that decreases aqueous humour formation and increases uveoscleral outflow, further reducing IOP.

For ophthalmic use only. Instill 1 drop into the affected eye(s) as prescribed (commonly twice daily). Shake well before use. Remove contact lenses before instillation; reinsert after 15 minutes. If using other eye medicines, keep a 5–10 minute gap.

Eye irritation/burning, blurred vision, dry eye, eye redness, foreign body sensation, bitter/abnormal taste, dry mouth, headache, fatigue/drowsiness

Do not use if allergic to brinzolamide/brimonidine or sulfonamides. Use caution in severe kidney impairment (brinzolamide is contraindicated in severe renal impairment) and in patients with cardiovascular disease, orthostatic hypotension, depression, Raynaud’s phenomenon, or cerebrovascular insufficiency (brimonidine may worsen). May cause drowsiness/blurred vision—avoid driving until clear. Avoid touching dropper tip to prevent contamination. Use in children only if prescribed. Tell your doctor if you have dry eye/corneal problems.

MAO inhibitors, tricyclic antidepressants (may affect brimonidine), CNS depressants/alcohol (additive sedation), antihypertensives/cardiac glycosides (additive blood pressure/heart rate effects), other carbonic anhydrase inhibitors (e.g., acetazolamide) may increase systemic effects, other glaucoma eye drops (additive IOP-lowering)

Store below 25°C. Protect from light and moisture. Do not freeze. Keep bottle tightly closed. Discard as per label/within recommended period after opening.

Simbrinza Eye Drops, Brinolar-B Eye Drops, Brimzol Eye Drops, Brinzomid-B Eye Drops, Brinzobri Eye Drops