Tofabrint 11MG Tab

Tablet

Treatment of moderate to severe rheumatoid arthritis, psoriatic arthritis, and moderate to severe ulcerative colitis (as prescribed by a specialist), usually when there is inadequate response/intolerance to other DMARDs/biologics

Tofacitinib is a Janus kinase (JAK) inhibitor that reduces signaling of multiple inflammatory cytokines. This lowers immune-mediated inflammation and helps relieve symptoms and prevent disease progression in autoimmune conditions.

Tablet (extended-release): take exactly as prescribed, usually once daily. Swallow whole with water; do not crush, break or chew. Can be taken with or without food; take at the same time each day. Regular lab monitoring (CBC, LFTs, lipids) is typically required.

Upper respiratory tract infection, headache, nausea, diarrhea, abdominal pain, increased cholesterol, elevated liver enzymes, herpes zoster (shingles), urinary tract infection

Prescription-only immunosuppressant. Increased risk of serious infections (TB, bacterial, fungal, viral) and reactivation (TB/hepatitis); screen for TB and hepatitis before therapy and monitor. Risk of malignancy (including lymphoma and skin cancer), major adverse cardiovascular events, blood clots (DVT/PE) and death—use with caution especially in older patients, smokers, and those with CV risk factors; seek urgent care for chest pain, breathlessness, leg swelling. Monitor CBC (risk of anemia/neutropenia/lymphopenia), liver function and lipids. Avoid live vaccines during treatment; complete immunizations before starting if possible. Use caution/adjustment in hepatic or renal impairment as advised by doctor.

Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase levels; strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, St John’s wort) may reduce effect; other immunosuppressants/biologics (e.g., azathioprine, cyclosporine, tacrolimus, TNF inhibitors) increase infection risk; live vaccines should be avoided

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Xeljanz XR 11 Tablet, Tofajak XR 11 Tablet, Tofacinix XR 11 Tablet, Tofalfa XR 11 Tablet, Tofaid XR 11 Tablet