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MSN LABORATORIES
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Important advisories specific to this medicine.
Pregnancy
Consult doctor (use with caution; limited human data)
Alcohol
Use with caution (may increase dizziness and risk of dehydration)
Treatment of hyponatremia (low blood sodium) associated with conditions like heart failure, liver cirrhosis and SIADH (syndrome of inappropriate antidiuretic hormone secretion); used under medical supervision to raise serum sodium.
Thirst, dry mouth, increased urination (polyuria), frequent urination, dehydration, dizziness, weakness, constipation, increased blood sodium (hypernatremia)
Tolvaptan is a selective vasopressin V2-receptor antagonist. It blocks the action of antidiuretic hormone in the kidneys, increasing excretion of free water (aquaresis) without significant loss of electrolytes, thereby increasing serum sodium.
Brand
MSN LABORATORIES
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Manufacturer: MSN LABORATORIES
Disclaimer: Product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalised guidance.
Sources: Manufacturer labeling/package insert, established medical literature, standard pharmacology references, Indian regulatory/marketed product information
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Treatment of hyponatremia (low blood sodium) associated with conditions like heart failure, liver cirrhosis and SIADH (syndrome of inappropriate antidiuretic hormone secretion); used under medical supervision to raise serum sodium.
Tolvaptan is a selective vasopressin V2-receptor antagonist. It blocks the action of antidiuretic hormone in the kidneys, increasing excretion of free water (aquaresis) without significant loss of electrolytes, thereby increasing serum sodium.
Take as prescribed by a doctor, usually once daily. Can be taken with or without food; swallow whole with water. Initiation and dose changes are typically done with close monitoring of sodium and hydration status; maintain adequate access to water and drink when thirsty.
Thirst, dry mouth, increased urination (polyuria), frequent urination, dehydration, dizziness, weakness, constipation, increased blood sodium (hypernatremia)
Use only under specialist supervision with regular monitoring of serum sodium to avoid overly rapid correction (risk of serious neurological injury). Risk of dehydration and low blood pressure—ensure adequate fluid intake. Tolvaptan can cause serious liver injury in some uses; monitor liver function if advised and stop if symptoms like fatigue, loss of appetite, right upper abdominal pain, dark urine or jaundice occur. Avoid in anuria, inability to sense/respond to thirst, hypovolemic hyponatremia, urgent need to raise sodium, or severe liver disease unless specifically directed. Use caution in kidney disease, elderly, and with diuretics.
Strong CYP3A inhibitors (ketoconazole, itraconazole, clarithromycin, ritonavir), CYP3A inducers (rifampicin, phenytoin, carbamazepine, St John’s wort), other diuretics, digoxin (may increase levels), grapefruit juice
Store at room temperature (below 25°C), in a dry place, protected from moisture and light. Keep out of reach of children.
Tolvaptan 30 mg tablets (other brands), Jinarc 30 mg (tolvaptan), Tolvapt 30 mg, Tolvafree 30 mg, Tolvance 30 mg
Take as prescribed by a doctor, usually once daily. Can be taken with or without food; swallow whole with water. Initiation and dose changes are typically done with close monitoring of sodium and hydration status; maintain adequate access to water and drink when thirsty.
Store at room temperature (below 25°C), in a dry place, protected from moisture and light. Keep out of reach of children.
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