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Treatment of diabetes mellitus to improve glycaemic control in adults, adolescents and children (typically type 1 and type 2 diabetes) as a long-acting basal insulin.

Insulin degludec is an ultra‑long acting basal insulin analogue. After subcutaneous injection it forms multi-hexamers that slowly release insulin, providing a stable, prolonged glucose-lowering effect for more than 24 hours.

For subcutaneous use only in a compatible insulin pen using Penfill cartridges. Inject once daily at the same time each day or, if needed, with flexible timing as advised by the doctor. Can be taken with or without food; rotate injection sites (abdomen, thigh, upper arm). Do not mix with other insulins in the same syringe/cartridge; not for IV use.

Hypoglycaemia, injection site reactions (pain/redness/swelling), weight gain, oedema, lipodystrophy (lipoatrophy/lipohypertrophy), rash, pruritus

Risk of hypoglycaemia (may impair driving/operating machinery); dose adjustments needed with changes in diet/exercise, intercurrent illness, renal/hepatic impairment. Do not use during episodes of hypoglycaemia. Avoid medication errors (confirm insulin name/strength); do not share pens/needles. Monitor for allergic reactions and injection-site lipodystrophy; rotate sites. Use with caution when switching from other insulins—requires close glucose monitoring.

Other antidiabetics (sulfonylureas, glinides) increase hypoglycaemia risk; beta-blockers may mask hypoglycaemia; corticosteroids, thiazide diuretics, thyroid hormones, sympathomimetics and danazol may increase glucose and insulin needs; ACE inhibitors, MAO inhibitors, salicylates and alcohol may enhance hypoglycaemic effect; pioglitazone with insulin may increase risk of fluid retention/heart failure.

Unopened: store refrigerated at 2–8°C, do not freeze; keep away from freezer compartment. In-use: may be kept at room temperature (generally below 30°C) or refrigerated as per label; protect from heat and direct light; keep cartridge in carton; discard if frozen or if solution is not clear/colorless.

Ryzodeg 70/30 Penfill, Lantus 100IU/ml Cartridge, Toujeo Solostar (insulin glargine U300), Levemir Penfill, Basaglar Cartridge