Distributor inventory | Tablet

Epilepsy/seizure disorders (generalized and focal seizures), prevention of migraine (as prescribed), bipolar disorder/mania (as prescribed)

Valproate increases levels of the inhibitory neurotransmitter GABA in the brain and modulates neuronal ion channels. This stabilizes overactive nerve firing, helping prevent seizures and mood episodes.

Take orally exactly as prescribed, usually once or twice daily. Swallow the controlled-release tablet whole with water; do not crush, chew or break. Can be taken with food to reduce stomach upset; take at the same time each day.

Nausea, vomiting, abdominal pain, indigestion, diarrhoea, dizziness, drowsiness, tremor, headache, weight gain, hair loss, increased appetite

Prescription-only medicine. Risk of severe liver injury and pancreatitis—seek urgent care for persistent vomiting, severe abdominal pain, jaundice, dark urine, unusual tiredness. May cause thrombocytopenia/bleeding; periodic liver function and blood counts are advised. Can cause sedation—avoid driving/machinery until you know the effect. Not recommended in pregnancy due to high risk of birth defects and neurodevelopmental disorders; ensure effective contraception and consult doctor before planning pregnancy. Do not stop abruptly (may trigger seizures). Use caution in kidney disease, liver disease, mitochondrial disorders, and in children.

Carbamazepine, phenytoin, phenobarbital and other antiepileptics (level changes), lamotrigine (increased risk of serious rash), topiramate (hyperammonemia/encephalopathy), warfarin/anticoagulants and antiplatelets (bleeding risk), aspirin (increases valproate levels/bleeding), benzodiazepines and other CNS depressants (increased sedation), rifampicin (reduced levels), carbapenem antibiotics e.g., meropenem/imipenem (markedly lowers valproate levels; avoid)

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Encorate Chrono 500 Tablet, Valparin CR 500 Tablet, Encorate Chrono 300 Tablet, Valparin CR 300 Tablet, Valprol CR 500 Tablet