Valrate CR 300

Valrate Cr 300 contains Sodium Valproate (200mg) + Valproic Acid (87mg) and is used for epilepsy/seizure disorders (including generalized and partial seizures). Prescription required.

Treatment of epilepsy/seizure disorders (including generalized and partial seizures); prevention of migraine (as prescribed); may also be used for bipolar disorder/mania under specialist care

Sodium valproate increases brain levels of the inhibitory neurotransmitter GABA and modulates neuronal ion channels, which stabilizes abnormal electrical activity in the brain. This helps prevent and control seizures and reduces neuronal hyperexcitability.

Oral controlled-release tablet: take exactly as prescribed, preferably at the same time each day. Swallow whole with water; do not crush, chew, or break. Can be taken with food to reduce stomach upset.

Nausea, vomiting, stomach pain, indigestion, diarrhea, increased appetite, weight gain, dizziness, drowsiness, tremor, hair loss, headache

Prescription medicine. Risk of serious liver injury and pancreatitis—seek urgent care for severe abdominal pain, persistent vomiting, jaundice, dark urine, unusual tiredness, or loss of seizure control. May cause thrombocytopenia/bleeding and hyperammonemia; periodic liver function tests and blood counts may be needed. Use caution in patients with liver disease, urea cycle disorders, or mitochondrial disorders. May impair alertness—avoid driving/operating machinery until you know its effect. Do not stop suddenly without medical advice.

Carbamazepine, phenytoin, phenobarbital/primidone, lamotrigine (increased risk of serious rash), topiramate (hyperammonemia), aspirin/salicylates (increased valproate levels/bleeding risk), warfarin/anticoagulants (bleeding risk), benzodiazepines and other CNS depressants (increased sedation), rifampicin (reduced levels)

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Valparin CR 300 Tablet, Encorate Chrono 300 Tablet, Valprol CR 300 Tablet, Divalproex ER 300 Tablet, Valence CR 300 Tablet