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10`S
Before you take it
Not recommended (high risk of birth defects and developmental disorders); use only if no suitable alternative and under strict specialist supervision
Valrate CR 300 Tablet is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.
Avoid (may increase drowsiness and dizziness; can worsen side effects)
Valrate CR 300 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Valrate CR 300 Tablet may not be needed in these patients. Please consult your doctor.<br>However, talk to your doctor if you have any underlying kidney disease.
Valrate CR 300 Tablet should be used with caution in patients with liver disease. Dose adjustment of Valrate CR 300 Tablet may be needed. Please consult your doctor.<br>Use of Valrate CR 300 Tablet is not recommended in patients with severe liver disease and active liver disease.
Monograph
Sodium Valproate (200mg) + Valproic Acid (87mg)
Treatment of epilepsy/seizure disorders (including generalized and partial seizures); prevention of migraine (as prescribed); may also be used for bipolar disorder/mania under specialist care
Sodium valproate increases brain levels of the inhibitory neurotransmitter GABA and modulates neuronal ion channels, which stabilizes abnormal electrical activity in the brain. This helps prevent and control seizures and reduces neuronal hyperexcitability.
Oral controlled-release tablet: take exactly as prescribed, preferably at the same time each day. Swallow whole with water; do not crush, chew, or break. Can be taken with food to reduce stomach upset.
Nausea, vomiting, stomach pain, indigestion, diarrhea, increased appetite, weight gain, dizziness, drowsiness, tremor, hair loss, headache
Prescription medicine. Risk of serious liver injury and pancreatitis—seek urgent care for severe abdominal pain, persistent vomiting, jaundice, dark urine, unusual tiredness, or loss of seizure control. May cause thrombocytopenia/bleeding and hyperammonemia; periodic liver function tests and blood counts may be needed. Use caution in patients with liver disease, urea cycle disorders, or mitochondrial disorders. May impair alertness—avoid driving/operating machinery until you know its effect. Do not stop suddenly without medical advice.
Carbamazepine, phenytoin, phenobarbital/primidone, lamotrigine (increased risk of serious rash), topiramate (hyperammonemia), aspirin/salicylates (increased valproate levels/bleeding risk), warfarin/anticoagulants (bleeding risk), benzodiazepines and other CNS depressants (increased sedation), rifampicin (reduced levels)
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.
Valparin CR 300 Tablet, Encorate Chrono 300 Tablet, Valprol CR 300 Tablet, Divalproex ER 300 Tablet, Valence CR 300 Tablet
At a glance
Good to know
Treatment of epilepsy/seizure disorders (including generalized and partial seizures); prevention of migraine (as prescribed); may also be used for bipolar disorder/mania under specialist care
Nausea, vomiting, stomach pain, indigestion, diarrhea, increased appetite, weight gain, dizziness, drowsiness, tremor, hair loss, headache
Sodium valproate increases brain levels of the inhibitory neurotransmitter GABA and modulates neuronal ion channels, which stabilizes abnormal electrical activity in the brain. This helps prevent and control seizures and reduces neuronal hyperexcitability.
Oral controlled-release tablet: take exactly as prescribed, preferably at the same time each day. Swallow whole with water; do not crush, chew, or break. Can be taken with food to reduce stomach upset.
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.
Yes, this product requires a valid prescription (Rx). Upload it during checkout when prompted.
Yes. Prices and availability can change based on inventory and serviceability. The latest details are shown at checkout.
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Brand
IPCA LABORATORIES LTD`
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Manufacturer: IPCA LABORATORIES LTD`
Medical disclaimer: product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalised guidance. Sources: Manufacturer labeling/pack insert, established medical literature (neurology/antiepileptic guidelines), standard drug references, Indian regulatory/marketed product information
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