
Acuclav 375
Macleods Pharmaceuticals Pvt Ltd - 10 S
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Caffeine (30mg) + Chlorpheniramine Maleate (2mg) + Paracetamol (500mg) + Phenylephrine (10mg)
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Macbery Cold is used for treatment of Common cold.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Macbery Cold contains Caffeine (30mg) + Chlorpheniramine Maleate (2mg) + Paracetamol (500mg) + Phenylephrine (10mg). It belongs to the Methylxanthine stimulant, Antihistamine / leukotriene antagonist, Para-aminophenol derivative and Expectorant / mucolytic / bronchodilator class of medicines.
Treatment of Common cold
Macbery Cold Tablet is a combination of four medicines: Caffeine, Chlorpheniramine Maleate, Paracetamol, and Phenylephrine, which relieves common cold symptoms.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macbery Cold Tablet may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Macbery Cold Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause a racing heart, tremor, vomiting and agitation. It can cause severe drowsiness, a fast heartbeat, confusion and, in children, agitation and fits. It can cause severe and sometimes fatal liver damage, often with no symptoms at all for the first day. It can cause vomiting, severe drowsiness, a racing heart and, with codeine, dangerously slow breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Macbery Cold are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding CONSULT YOUR DOCTOR |
| Alcohol | Alcohol CONSULT YOUR DOCTOR |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver UNSAFE |
| Habit forming | No |
Count your tea, coffee and cola for the day — the caffeine in this medicine adds to them. Taken late in the day it can keep you awake. Painkillers with caffeine taken most days can themselves cause a daily headache. If you are reaching for them more than twice a week, see a doctor rather than taking more. Older antihistamines cause marked drowsiness — do not drive or operate machinery until you know how this affects you. Tell your doctor promptly about any change in mood, sleep, agitation or unusual thoughts while taking montelukast; this is uncommon but recognised. This relieves the symptoms of an allergy; it does not treat the cause, and it is not a treatment for an acute asthma attack. Seek emergency care for swelling of the lips, tongue or throat, or difficulty breathing. Never exceed the daily maximum printed on the pack. Paracetamol overdose damages the liver, and the damage can be silent for a day or two before it becomes serious. Check every other medicine you are taking. Paracetamol is in a very large number of cold, flu and pain combinations, and the doses add together. If you drink alcohol regularly, or have liver disease, ask your doctor what daily limit is safe for you. See a doctor if fever lasts more than three days, or pain more than five. See a doctor if a cough lasts more than a week, or comes with fever, breathlessness, chest pain or blood in the sputum. Do not give cough and cold preparations to young children except on a doctor's advice. Do not combine two cough preparations — they frequently contain the same ingredients, and the doses add up. Preparations containing codeine can cause dependence and must be used only for the period your doctor specifies.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for anyone with an uncontrolled heart rhythm problem, unless a doctor has said otherwise. The sedating antihistamines are not suitable for very young children, or for people with glaucoma or an enlarged prostate, without medical advice. Not for people with severe liver disease, except under medical supervision. Codeine-containing preparations are not for children, or for anyone with breathing difficulty.
Tell your doctor if you take medicines for asthma, a heart rhythm problem, or an antibiotic of the ciprofloxacin family — caffeine lasts longer alongside some of them. Alcohol, sleeping tablets and other sedating medicines add to the drowsiness. Tell your doctor about all cold and cough preparations — many already contain an antihistamine. Regular alcohol use increases the risk of liver injury. Tell your doctor if you are on warfarin — regular high-dose paracetamol can affect it. Sedating ingredients add to the effect of alcohol and sleeping tablets. Decongestants such as phenylephrine and pseudoephedrine can raise blood pressure — tell your doctor if you are hypertensive.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Macbery Cold Tablet is prescribed to get relief from symptoms of common cold. Take exactly as directed by your doctor or on the label. Do not increase the dosage or take for longer than is recommended. Inform your doctor if you are taking any other medications for cold. Call your doctor if your symptoms have not improved within seven days of treatment or if you develop a fast, pounding, or uneven heartbeat, severe dizziness or anxiety, severe headache, fever, or rash. Inform your doctor if you are taking any antidepressants. Along with taking Macbery Cold Tablet do the following simple tips at home to get relief: Steam inhalation Gargling with warm saltwater. Apply vapor rubs on chest, back if needed. Take enough rest. Take warm food and fluid only. Ensure adequate fluid intake. Advise hygiene measures to reduce spread: frequent hand-washing, avoiding sharing towels, pillowcases, etc.

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The information on Macbery Cold is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.