Macorate CR 500 mg Tablet

Composition of Macorate CR 500 mg Tablet

Macorate CR 500 mg Tablet contains Magnesium Valproate (500mg). It belongs to the Anticonvulsant (valproate; GABA-enhancing agent) class of medicines.

Uses of Macorate CR 500 mg Tablet

• Treatment of epilepsy/seizure disorders (partial and generalized seizures)
• prevention of migraine (as prescribed)
• management of manic episodes in bipolar disorder (as prescribed)

Key benefits

• Controls and prevents seizures
• Helps stabilize mood in bipolar disorder
• Helps prevent migraine attacks
• Reduces abnormal electrical activity in the brain

How Macorate CR 500 mg Tablet works

Sodium valproate increases levels of the inhibitory neurotransmitter GABA in the brain and reduces abnormal neuronal firing. This helps stabilize electrical activity and prevents seizures/mood swings.

How to take Macorate CR 500 mg Tablet

Swallow the controlled-release tablet whole with water; do not crush or chew. Take at the same time each day, preferably with food to reduce stomach upset. Dose and duration are as prescribed; do not stop abruptly without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Macorate CR 500 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n

If you take too much

Taking more Macorate CR than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Macorate CR 500 mg Tablet

Most side effects of Macorate CR are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• stomach pain
• diarrhoea
• dizziness
• drowsiness
• tremor
• weight gain
• hair loss
• increased appetite
• headache

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Macorate CR 500 mg Tablet

Warnings and precautions

Risk of severe liver injury and pancreatitis—seek urgent care for severe abdominal pain, persistent vomiting, jaundice, dark urine or unusual tiredness. Can cause birth defects and developmental disorders; avoid in pregnancy unless clearly needed and under specialist advice. Monitor liver function and blood counts as advised; caution in patients with liver disease, bleeding disorders, or history of pancreatitis. May cause drowsiness—avoid driving/operating machinery if affected. Do not stop suddenly; may worsen seizures.

Interactions with other medicines

Other antiepileptics (phenytoin, carbamazepine, phenobarbital, lamotrigine, topiramate), aspirin/salicylates, warfarin and other anticoagulants/antiplatelets, CNS depressants (benzodiazepines, opioids, alcohol), rifampicin, erythromycin, carbapenem antibiotics (e.g., meropenem) which can markedly reduce valproate levels

How to store Macorate CR 500 mg Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Expert advice for Macorate CR 500 mg Tablet

It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. Monitor your weight during treatment with this medicine as it can cause weight gain. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency. Take your medication regularly as directed by your doctor as missing doses can trigger seizures. Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you. Some healthy tips to prevent seizures: Practice yoga every day. Get enough sleep at nighttime. Limit the use of screen time such as mobile/laptop. Take your medication on time. Macorate CR 500 Tablet helps in the treatment and prevention of seizures. Take it at the same time every day to maintain consistent levels in your body. It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. Avoid consuming alcohol when taking Macorate CR 500 Tablet, as it may cause excessive sleepiness or drowsiness. Monitor your weight during treatment with this medicine as it can cause weight gain. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Do not take Macorate CR 500 Tablet if you are pregnant or planning to conceive or breastfeeding. Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency. Take your medication regularly as directed by your doctor as missing doses can trigger seizures. Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you. Some healthy tips to prevent seizures: Practice yoga every day. Get enough sleep at nighttime. Li

Manufacturer and class

Manufacturer:

SUN PHARMA

Therapeutic class:

Antiepileptic / Mood stabilizer

Drug class:

Anticonvulsant (valproate; GABA-enhancing agent)

Chemical class:

Methyl- branched fatty acids