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Prescription requiredRpg Life Sciences LimitedAnalgesic and anti-inflammatory and Anti-emetic

Naprosyn D 500

Naproxen + Domperidone

Naprosyn D 500 is used for this medicine is used in the treatment of pain, inflammation, arthritis, fever, period pain, nausea, vomiting, bloating and slow stomach emptying.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

₹113
Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Naproxen + Domperidone
Available variants: NA 10`S
Best price: ₹113
Prescription: Required
Manufacturer: RPG LIFE SCIENCES LIMITED

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Naprosyn D 500

Naprosyn D 500 contains Naproxen + Domperidone. It belongs to the Non-steroidal anti-inflammatory drug and Anti-emetic / prokinetic class of medicines.

Uses of Naprosyn D 500

  • This medicine is used in the treatment of pain
  • inflammation
  • arthritis
  • fever
  • period pain
  • nausea
  • vomiting
  • bloating and slow stomach emptying.

Key benefits

  • Relieves pain and the swelling that causes it
  • Effective in arthritis and injury
  • Rapid relief of nausea and vomiting
  • Helps bloating and early fullness

How Naprosyn D 500 works

This medicine combines 2 active ingredients: Naproxen and Domperidone. Naproxen blocks the chemicals your body makes at a site of injury or inflammation, which reduces pain, swelling and fever. Domperidone settles the stomach and blocks the signals that trigger nausea and vomiting, and helps the stomach empty at a normal rate.

How to take Naprosyn D 500

Use this medicine as your doctor has directed. Follow the dose and the duration written on your prescription.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause stomach bleeding, kidney failure, drowsiness and fits. It can cause drowsiness, disorientation and abnormal muscle movements. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Naprosyn D 500

Most side effects of Naprosyn D are mild and settle as the body adjusts. Reported side effects include:

  • Indigestion
  • Stomach pain
  • Nausea
  • Heartburn
  • Dizziness
  • Swelling of the ankles and feet
  • Dry mouth
  • Drowsiness
  • Headache
  • Loose motions
  • Restlessness

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Naprosyn D 500

PregnancyNot recommended in pregnancy — it may harm the developing baby. Tell your doctor at once if you are or might be pregnant.
BreastfeedingConsult your doctor before using this while breastfeeding.
AlcoholDo not drink alcohol while taking this medicine.
DrivingMay cause drowsiness or affect your concentration. Do not drive until you know how it affects you.
KidneyConsult your doctor if you have kidney disease.
LiverConsult your doctor if you have liver disease.
Habit formingNo

Warnings and precautions

Take it with or just after food, and for the shortest time that works. Stop and seek urgent care for black or tarry stools, vomiting blood, or severe stomach pain — this group can cause bleeding from the stomach. Long or high-dose use raises the risk of heart attack, stroke and kidney injury, particularly in older people and those already at risk. Avoid if you are dehydrated or have an illness with vomiting or loose motions — the kidneys are vulnerable then. Must be avoided in the last three months of pregnancy. Use it for the shortest period that works. These medicines are not intended for long-term daily use. Report any unusual muscle stiffness, tremor, restlessness or uncontrolled movements of the face or limbs at once — stop and contact your doctor. Tell your doctor if you have a heart rhythm problem; some of this group affect the heart's electrical timing. Persistent vomiting needs a diagnosis. Do not keep suppressing it without seeing a doctor, especially with abdominal pain, fever or blood.

Do not take Naprosyn D if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with an active stomach ulcer, severe kidney or heart failure, or asthma triggered by aspirin or anti-inflammatory painkillers. Not in the third trimester of pregnancy. Not for people with bleeding, blockage or perforation of the gut, or with certain heart rhythm disorders.

Interactions with other medicines

Combining with a blood thinner or aspirin sharply raises the bleeding risk. Reduces the effect of blood pressure medicines and water tablets, and together with them can harm the kidneys. Never take two anti-inflammatory painkillers at the same time. Antifungals, some antibiotics and heart-rhythm medicines increase the risk of rhythm problems when combined. Adds to the drowsiness of alcohol and sedatives.

How to store Naprosyn D 500

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Naprosyn D 500

Use the lowest dose for the shortest period. If you need a painkiller regularly, see your doctor rather than continuing on your own. Paracetamol is the safer choice for simple fever and headache. Take it shortly before meals for bloating and early fullness. Sip fluids frequently in small amounts, and use oral rehydration salts if you have been vomiting.

Manufacturer and class

Manufacturer:
RPG LIFE SCIENCES LIMITED
Therapeutic class:
Analgesic and anti-inflammatory and Anti-emetic
Drug class:
Non-steroidal anti-inflammatory drug and Anti-emetic / prokinetic

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Naprosyn D 500 FAQs

What is Naprosyn D 500 used for?
Naprosyn D 500 is commonly used for This medicine is used in the treatment of pain, inflammation, arthritis, fever, period pain, nausea, vomiting, bloating and slow stomach emptying. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Naprosyn D 500?
Naprosyn D 500 contains Naproxen + Domperidone. If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Naprosyn D 500?
Use this medicine as your doctor has directed. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Naprosyn D 500 work?
This medicine combines 2 active ingredients: Naproxen and Domperidone.
Is Naprosyn D 500 a prescription medicine?
Yes. Naprosyn D 500 is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Naprosyn D 500?
The side effects reported most often with Naprosyn D are Indigestion, Stomach pain, Nausea, Heartburn, Dizziness. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Naprosyn D 500 be taken during pregnancy?
Not recommended in pregnancy — it may harm the developing baby. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Naprosyn D.
Can I drink alcohol while taking Naprosyn D 500?
Do not drink alcohol while taking this medicine.
What if I miss a dose of Naprosyn D 500?
Take it as soon as you remember.
Is Naprosyn D 500 habit forming?
No. Naprosyn D 500 is not known to be habit forming when taken as prescribed.
How much does Naprosyn D 500 cost on PingMeDoc Pharmacy?
Naprosyn D 500 starts at ₹113 on PingMeDoc Pharmacy. Available in NA 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Naprosyn D 500?
Naprosyn D 500 is manufactured by RPG LIFE SCIENCES LIMITED. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Naprosyn D 500 delivered?
Naprosyn D 500 is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Naprosyn D 500, Quick facts

Salt
Naproxen + Domperidone
Best price
₹113
Prescription
Required (Rx)
Brand
RPG LIFE SCIENCES LIMITED
Manufacturer
RPG LIFE SCIENCES LIMITED
Therapeutic class
Analgesic and anti-inflammatory and Anti-emetic
Drug class
Non-steroidal anti-inflammatory drug and Anti-emetic / prokinetic
Habit forming
No
Variants
NA 10`S
Delivery
Standard across India

References

The information on Naprosyn D 500 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Naprosyn D 500.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.