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Prescription requiredSaffron PharmaceuticaGASTRO INTESTINAL

Sibocure 400 Tablet

Rifaximin (400mg)

Currently out of stock

Same composition, in stock now. Check with your doctor or pharmacist before you switch.

  • Rifalix 400 Tablet₹309View
  • Ciboz 400 mg Tablet₹324View
  • Rifaxigress 400 mg Tablet₹335View

Sibocure 400 Tablet is used for treatment of Infectious diarrhea.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

Licensed pharmacyPharmacist-verified order

Key details

Salt: Rifaximin (400mg)
Available variants: tablet 400mg 10`S
Best price: ₹303 (₹30.28 per tablet)
MRP: ₹319
Prescription: Required
Manufacturer: SAFFRON PHARMACEUTICA

Ordering notes

Delivery details are shown when the medicine is back in stock.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Sibocure 400 Tablet

Sibocure 400 Tablet contains Rifaximin (400mg). It belongs to the Antibacterial agent class of medicines.

Uses of Sibocure 400 Tablet

Treatment of Infectious diarrhea

Key benefits

  • In Treatment of Infectious diarrhea Infectious diarrhea is a condition characterized by the sudden onset of loose or watery stools caused by harmful microorganisms in the digestive system. Sibocure 400 Tablet helps treat infectious diarrhea by targeting and stopping the growth of harmful bacteria in the intestines. This medicine interferes with the bacteria's ability to make important proteins they need to survive and multiply. This helps to get rid of the bad bacteria causing the infection
  • which in turn reduces the diarrhea and helps you feel better.

How Sibocure 400 Tablet works

Sibocure 400 Tablet is an antibiotic. It works by killing the ammonia-producing bacteria in the digestive tract. This treats your infection and relieves symptoms of hepatic encephalopathy (agitation, confusion, muscle problems). This also helps reduce the recurrence of episodes of hepatic encephalopathy.

How to take Sibocure 400 Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sibocure 400 Tablet may be taken with or without food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Sibocure 400 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause vomiting, severe loose motions and nerve symptoms. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Sibocure 400 Tablet

Most side effects of Sibocure are mild and settle as the body adjusts. Reported side effects include:

  • Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Sibocure 400 Tablet

PregnancyConsult doctor
BreastfeedingBreast feeding CONSULT YOUR DOCTOR
AlcoholConsult doctor
DrivingDriving CONSULT YOUR DOCTOR
KidneyKidney CONSULT YOUR DOCTOR
LiverLiver CAUTION
Habit formingNo

Warnings and precautions

Finish the whole course even after you feel better. Do not drink any alcohol while taking metronidazole, ornidazole or tinidazole, or for the period after the course that your doctor states — the combination causes severe flushing, vomiting and a racing heart. Report severe or watery loose motions during or after the course rather than treating them yourself. Tetracyclines stain developing teeth and are avoided in young children and in pregnancy. Antibiotics do not work against colds, flu or most sore throats, which are caused by viruses.

Do not take Sibocure if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack.

Interactions with other medicines

Antacids, iron, zinc and calcium reduce the absorption of tetracyclines — separate them by a couple of hours. Tell your doctor if you take a blood thinner.

How to store Sibocure 400 Tablet

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Expert advice for Sibocure 400 Tablet

Sibocure 400 Tablet reduces the risk of overt hepatic encephalopathy (HE) recurrence in patients with liver disease. It may cause reddish discoloration of urine. This is normal and harmless. Stop taking Sibocure 400 Tablet and inform your doctor if you have severe diarrhea during or after using Sibocure 400 Tablet. Finish the full course of the medication, even if you feel better.

Manufacturer and class

Manufacturer:
SAFFRON PHARMACEUTICA
Therapeutic class:
GASTRO INTESTINAL
Drug class:
Antibacterial agent
Chemical class:
Macrolactams

Substitutes for Sibocure 400 Tablet

Medicines with the same active ingredient (Rifaximin (400mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Sibocure 400 Tablet
Rifalix 400 Tablet1X10₹3092% more
Ciboz 400 mg TabletZYDUS HEALTHCARE PHARMAtablet · 10`S₹3247% more
Rifaxigress 400 mg TabletLARENONtablet · 10`S₹33511% more
Rifasmart 400 mg TabletMANKIND (PHARMA)tablet · 10`S₹33811% more
Riforte 400 TabletSamarth Life Sciences Pvt Ltdtablet · 10`S₹35818% more
Rifaximax 400 TabletZuventus Healthcare Ltdtablet · 10`S₹37123% more
Rifakem 400 mg TabletALKEM LABtablet · 10`S₹40734% more
Rifagut 400 mg TabletSUN PHARMAtablet · 10`S₹42841% more
Dirifa 400 mg TabletAbbott India Limitedtablet · 10`S₹45149% more
Torfix 400 mg TabletTorrent Pharmaceuticals Ltdtablet · 10`S₹45651% more
Sibofix 400 mg TabletDr Reddys Laboratories Ltdtablet · 10`S₹46353% more
Zimigut 400 mg TabletIntas Pharmaceuticals Ltdtablet · 10`S₹50667% more
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Sibocure 400 Tablet FAQs

What is Sibocure 400 Tablet used for?
Sibocure 400 Tablet is commonly used for Treatment of Infectious diarrhea. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Sibocure 400 Tablet?
Sibocure 400 Tablet contains Rifaximin (400mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Sibocure 400 Tablet?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Sibocure 400 Tablet work?
Sibocure 400 Tablet is an antibiotic.
Is Sibocure 400 Tablet a prescription medicine?
Yes. Sibocure 400 Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Sibocure 400 Tablet?
The side effects reported most often with Sibocure are Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Sibocure 400 Tablet be taken during pregnancy?
Consult doctor Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Sibocure.
Can I drink alcohol while taking Sibocure 400 Tablet?
Consult doctor
What if I miss a dose of Sibocure 400 Tablet?
If you miss a dose of Sibocure 400 Tablet, take it as soon as possible.
Is Sibocure 400 Tablet habit forming?
No. Sibocure 400 Tablet is not known to be habit forming when taken as prescribed.
How much does Sibocure 400 Tablet cost on PingMeDoc Pharmacy?
Sibocure 400 Tablet starts at ₹303 (MRP ₹319) on PingMeDoc Pharmacy. Available in tablet 400mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Sibocure 400 Tablet?
Sibocure 400 Tablet is manufactured by SAFFRON PHARMACEUTICA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Sibocure 400 Tablet delivered?
Sibocure 400 Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Sibocure 400 Tablet, Quick facts

Salt
Rifaximin (400mg)
Form
tablet
Best price
₹303 (₹30.28 per tablet)
MRP
₹319
Prescription
Required (Rx)
Schedule
Schedule H
Brand
SAFFRON PHARMACEUTICA
Manufacturer
SAFFRON PHARMACEUTICA
Therapeutic class
GASTRO INTESTINAL
Drug class
Antibacterial agent
Chemical class
Macrolactams
Action class
RNA polymerase inhibitors- Rifamycins
Habit forming
No
Variants
tablet 400mg 10`S
Delivery
Standard across India

References

The information on Sibocure 400 Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. Manufacturer labeling/pack information
  2. Indian drug market listings, established medical literature
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Sibocure 400 Tablet.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.