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Brinzolamide 1% w/v + Brimonidine tartrate 0.2% w/v ophthalmic suspension
Treatment of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension
Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humour production in the eye, lowering intraocular pressure. Brimonidine is an alpha-2 adrenergic agonist that decreases aqueous humour formation and increases uveoscleral outflow, further reducing IOP.
For ophthalmic use only. Instill 1 drop into the affected eye(s) as prescribed (commonly twice daily). Shake well before use. Remove contact lenses before instillation; reinsert after 15 minutes. If using other eye medicines, keep a 5–10 minute gap.
Common side effects of SIMBRINZA DROPS may include:
Do not use if allergic to brinzolamide/brimonidine or sulfonamides. Use caution in severe kidney impairment (brinzolamide is contraindicated in severe renal impairment) and in patients with cardiovascular disease, orthostatic hypotension, depression, Raynaud’s phenomenon, or cerebrovascular insufficiency (brimonidine may worsen). May cause drowsiness/blurred vision—avoid driving until clear. Avoid touching dropper tip to prevent contamination. Use in children only if prescribed. Tell your doctor if you have dry eye/corneal problems.
