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Sun Pharma 2 - 100 G
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Clindamycin (1% w/w) + Tretinoin (0.04% w/w)
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Supatret 0.04 Aqueous Gel is used for treatment of Acne.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Supatret 0.04 Aqueous Gel contains Clindamycin (1% w/w) + Tretinoin (0.04% w/w). It belongs to the Antibacterial agent and Retinoid / keratolytic class of medicines.
Treatment of Acne
Supatret C Aqueous Gel is a combination of two medicines: Clindamycin and Tretinoin, which treats pimples (acne). Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria. Tretinoin is a form of vitamin A which reduces oil production in the skin, replenishes the skin and helps keep your pores open.
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Supatret C Aqueous Gel, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause vomiting, severe loose motions and nerve symptoms. It can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Supatret are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy UNSAFE |
|---|---|
| Breastfeeding | Breast feeding CAUTION |
| Alcohol | Alcohol |
| Driving | Driving |
| Kidney | Kidney |
| Liver | Liver |
| Habit forming | No |
Finish the whole course even after you feel better. Do not drink any alcohol while taking metronidazole, ornidazole or tinidazole, or for the period after the course that your doctor states — the combination causes severe flushing, vomiting and a racing heart. Report severe or watery loose motions during or after the course rather than treating them yourself. Tetracyclines stain developing teeth and are avoided in young children and in pregnancy. Antibiotics do not work against colds, flu or most sore throats, which are caused by viruses. Acne often looks worse for the first two to four weeks before it improves. This is expected — do not stop. Use sunscreen every day. These medicines make the skin burn much more easily. Oral isotretinoin must never be taken in pregnancy — it causes severe birth defects. Reliable contraception and the pregnancy tests your dermatologist requires are essential before, during and after the course. Start with alternate nights and build up, and do not use more than a pea-sized amount for the whole face. Do not combine several strong acne actives at once without advice — the irritation compounds.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy.
Antacids, iron, zinc and calcium reduce the absorption of tetracyclines — separate them by a couple of hours. Tell your doctor if you take a blood thinner. Do not combine with other peeling agents or with waxing and harsh scrubs. Oral retinoids must not be combined with tetracycline antibiotics.
Store below 30°C, away from direct sunlight. Close the cap tightly after each use. Keep out of the reach of children.
Supatret C Aqueous Gel should be Applied as a thin layer onto clean, dry, unbroken skin affected by acne. Clean the area to be treated with water and a non-medicated soap, and let it dry for 20-30 minutes before applying the medicine. It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away. Avoid contact with your eyes, nose or mouth. Rinse it off with water if you accidentally get the cream in these areas. Avoid exposure to sunlight while using Supatret C Aqueous Gel as it increases the sensitivity of your skin. Use protective measures such as sun-cream or protective clothing. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

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The information on Supatret 0.04 Aqueous Gel is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.