Tofasure 5 mg Tablet

Composition of Tofasure 5 mg Tablet

Tofasure 5 mg Tablet contains Tofacitinib (5mg). It belongs to the Janus kinase (JAK) inhibitor class of medicines.

Uses of Tofasure 5 mg Tablet

• Treatment of rheumatoid arthritis (moderate to severe) in adults
• psoriatic arthritis in adults
• ulcerative colitis (moderate to severe) in adults (as prescribed by specialist)

Key benefits

• Reduces joint pain and swelling in rheumatoid arthritis
• Improves physical function and slows inflammatory damage
• Helps control symptoms in psoriatic arthritis
• Induces/maintains remission in ulcerative colitis (as prescribed)

How Tofasure 5 mg Tablet works

Tofacitinib is a Janus kinase (JAK) inhibitor. It blocks JAK-mediated signaling of inflammatory cytokines, thereby reducing immune activation, inflammation, pain, and joint/intestinal symptoms.

How to take Tofasure 5 mg Tablet

Tablet for oral use. Take exactly as prescribed by the doctor, usually 5 mg once or twice daily depending on indication. Can be taken with or without food; swallow whole with water at the same time each day. Do not stop or change dose without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Tofasure 5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can seriously suppress the bone marrow and damage the liver. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Tofasure 5 mg Tablet

Most side effects of Tofasure are mild and settle as the body adjusts. Reported side effects include:

• Upper respiratory tract infection
• headache
• nausea
• diarrhea
• increased cholesterol
• elevated liver enzymes
• hypertension
• herpes zoster (shingles)
• urinary tract infection

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Tofasure 5 mg Tablet

Warnings and precautions

Prescription-only immunosuppressant. Increased risk of serious infections (TB, fungal, bacterial, viral) and reactivation of TB/hepatitis; screening may be needed before starting. Risk of blood clots (DVT/PE), major cardiovascular events, and malignancy may increase in some patients—use lowest effective dose and follow specialist advice. Monitor CBC, liver enzymes, lipids; watch for signs of infection. Use caution in liver/kidney impairment. Avoid live vaccines during treatment.

Do not take Tofasure if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with an active serious infection, or with severe liver or bone-marrow disease. Several of these medicines must not be used in pregnancy.

Interactions with other medicines

Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase levels; strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin) may reduce effect. Immunosuppressants/biologics (e.g., azathioprine, cyclosporine, tacrolimus, TNF inhibitors) increase infection risk—generally avoid combination. Live vaccines should be avoided.

How to store Tofasure 5 mg Tablet

Store at room temperature (below 25°C), in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Expert advice for Tofasure 5 mg Tablet

Tofasure 5 Tablet is used alone or in combination with other medicines for the treatment of rheumatoid arthritis, that did not improve with other anti-rheumatic drugs. It may take take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed. Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts, or cholesterol levels. Tofasure 5 Tablet can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches. Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Manufacturer and class

Manufacturer:

CANIXA LIFE SCIENCE

Therapeutic class:

Immunosuppressant / Antirheumatic

Drug class:

Janus kinase (JAK) inhibitor

Chemical class:

N- acylpiperidines