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Ofloxacin (400mg)
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Same composition, in stock now. Check with your doctor or pharmacist before you switch.
Zo-400 is used for treatment of Bacterial infections.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Zo-400 contains Ofloxacin (400mg). It belongs to the Fluoroquinolone class of medicines.
Treatment of Bacterial infections
ZO 400mg Tablet is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. ZO 400mg Tablet may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of ZO 400mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause kidney injury, fits and heart rhythm disturbance. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Zo-400 are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding UNSAFE |
| Alcohol | Alcohol CAUTION |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver CAUTION |
| Habit forming | No |
Stop and contact your doctor at once if you develop pain, swelling or tenderness in a tendon — the Achilles tendon at the back of the ankle in particular. This group can damage tendons, and the risk is higher in older people and with steroids. Report any new numbness, tingling or burning in the hands or feet promptly. Tell your doctor about any change in mood, confusion or agitation. Avoid strong sunlight and use sun protection — this group makes the skin burn more easily. Finish the whole course; this group is heavily associated with antibiotic resistance and should be used only when prescribed.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Generally avoided in children and adolescents, in pregnancy, and in anyone with a history of tendon problems with these antibiotics.
Antacids, iron, zinc, calcium and milk markedly reduce absorption — separate them by at least two hours. Tell your doctor if you take steroids, a blood thinner or a medicine for heart rhythm.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Do not skip any doses and finish the full course of treatment even if you feel better. Discontinue ZO 400mg Tablet and inform your doctor immediately if you get a rash, itchy skin, swelling of the face and mouth, or have difficulty breathing. Diarrhea may occur as a side effect, but it should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations. Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Medicines with the same active ingredient (Ofloxacin (400mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Zo-400 |
|---|---|---|---|
| Zenflox-400MANKIND (PHARMA) | 10`S | ₹162 | 48% more |
| Onoff 400 mg Tablet | 1X10 | ₹163 | 50% more |
| Oflomac 400 TabletMacleods Pharmaceuticals Pvt Ltd | tablet · 10 Tablet | ₹187 | 71% more |
| Oflin 400 mg TabletZYDUS HEALTHCARE PHARMA | tablet · 10`S | ₹245 | 124% more |
| Zanocin OD 400 mgSUN PHARMA 2 | 5`S | ₹249 | 128% more |
| Oflochem 400 mg Tablet | 1 | ₹269 | 146% more |
| Zanocin DS 400 mgSUN PHARMA 2 | 10`S | ₹281 | 157% more |
| Oflox 400CIPLA LIMITED | 10`S | ₹381 | 249% more |
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The information on Zo-400 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.