
Acuclav 375
Macleods Pharmaceuticals Pvt Ltd - 10 S
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Sulbactam (500mg) + Cefoperazone (1000mg)
Currently out of stock
Same composition, in stock now. Check with your doctor or pharmacist before you switch.
Zonamax Es is used for zonamax ES 1000 mg/500 mg Injection is used in the treatment of bacterial infections.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Zonamax Es contains Sulbactam (500mg) + Cefoperazone (1000mg). It belongs to the Penicillin and Cephalosporin class of medicines.
Zonamax ES 1000 mg/500 mg Injection is used in the treatment of bacterial infections.
Zonamax ES 1000 mg/500 mg Injection is a combination of two medicines: Cefoperazone and Sulbactam. Cefoperazone is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Sulbactam is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Cefoperazone against bacteria.
Take exactly as prescribed by your doctor.
Most side effects of Zonamax Es are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Zonamax ES 1000 mg/500 mg Injection is probably safe to use during pregnancy.<br>Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor. |
|---|---|
| Breastfeeding | Zonamax ES 1000 mg/500 mg Injection is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby. |
| Alcohol | Zonamax ES 1000 mg/500 mg Injection may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions). |
| Driving | Not expected to affect your ability to drive. |
| Kidney | There is limited information available on the use of Zonamax ES 1000 mg/500 mg Injection in patients with kidney disease. Please consult your doctor. |
| Liver | There is limited information available on the use of Zonamax ES 1000 mg/500 mg Injection in patients with liver disease. Please consult your doctor. |
| Habit forming | No |
Finish the whole course even after you feel better. Stopping early lets the strongest bacteria survive, and they are the ones that come back resistant. Stop and seek emergency care for swelling of the face or throat, difficulty breathing, or a widespread rash — a penicillin allergy can be serious. Tell every doctor and pharmacist if you have ever reacted to penicillin. Tell your doctor if loose motions become severe or watery, or continue after the course — this needs attention rather than an anti-diarrhoeal. Antibiotics do not work against colds, flu or most sore throats, which are caused by viruses. Finish the whole course even after you feel better — stopping early breeds resistant bacteria. Tell your doctor if you have ever had a severe reaction to penicillin; a small proportion of people react to both groups. Report severe or watery loose motions during or after the course rather than treating them yourself. Several medicines in this group are on Schedule H1 precisely because overuse drives antibiotic resistance. Take it only when a doctor has prescribed it for you.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for anyone with a known penicillin allergy. Not for anyone with a known allergy to cephalosporin antibiotics.
May reduce the reliability of the oral contraceptive pill if you have vomiting or loose motions — use additional precautions during the course. Tell your doctor if you take methotrexate or a blood thinner. Antacids, iron and zinc reduce absorption — separate them by a couple of hours. Tell your doctor if you take a blood thinner.
Store as printed on the carton — some injections need refrigeration and must not be frozen. Keep out of the reach of children.
<div class="style__desktop-container___1hcBT"><div class="style__desktop-video___2GTR9"><div class="styles__video-img___1rCzR"><div class=""/><div class=""/></div></div><div><div><div><div><div class="ExpertAdviceItem__content___1Djk2"><ul><li>You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance. </li> <li>Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.</li> <li>Diarrhea may occur as a side effect. Taking probiotics along with Zosul 1.5gm Injection may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.</li> <li>Stop taking Zosul 1.5gm Injection and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.</li></ul></div></div></div></div></div></div>
Medicines with the same active ingredient (Sulbactam (500mg) + Cefoperazone (1000mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Zonamax Es |
|---|---|---|---|
| Izone-S InjectionEYSYS PHARMA | injection · VIAL | ₹264 | 47% more |
| Lactagard 1500 InjectionIPCA LABORATORIES LTD` | injection · 1`S | ₹338 | 89% more |
| Zofactum 1.5 g Injection | 1*20 | ₹454 | 153% more |

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The information on Zonamax Es is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.