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Prescription requiredMacleods Pharmaceuticals Pvt LtdAntibiotic

Zonamax Es

Sulbactam (500mg) + Cefoperazone (1000mg)

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Same composition, in stock now. Check with your doctor or pharmacist before you switch.

  • Izone-S Injection₹264View
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  • Zofactum 1.5 g Injection₹454View

Zonamax Es is used for zonamax ES 1000 mg/500 mg Injection is used in the treatment of bacterial infections.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

Licensed pharmacyPharmacist-verified order

Key details

Salt: Sulbactam (500mg) + Cefoperazone (1000mg)
Available variants: vial VIAL
Best price: ₹179
MRP: ₹188
Prescription: Required
Manufacturer: MACLEODS PHARMACEUTICALS LTD

Ordering notes

Delivery details are shown when the medicine is back in stock.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Zonamax Es

Zonamax Es contains Sulbactam (500mg) + Cefoperazone (1000mg). It belongs to the Penicillin and Cephalosporin class of medicines.

Uses of Zonamax Es

Zonamax ES 1000 mg/500 mg Injection is used in the treatment of bacterial infections.

Key benefits

  • Long-established and effective
  • Works against a wide range of common infections
  • Effective against a wide range of bacteria
  • Available as tablets
  • syrups and injections

How Zonamax Es works

Zonamax ES 1000 mg/500 mg Injection is a combination of two medicines: Cefoperazone and Sulbactam. Cefoperazone is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Sulbactam is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Cefoperazone against bacteria.

How to take Zonamax Es

Take exactly as prescribed by your doctor.

Side effects of Zonamax Es

Most side effects of Zonamax Es are mild and settle as the body adjusts. Reported side effects include:

  • Diarrhea Altered liver function test Allergic reaction Anemia (low number of red blood cells)

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zonamax Es

PregnancyZonamax ES 1000 mg/500 mg Injection is probably safe to use during pregnancy.<br>Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
BreastfeedingZonamax ES 1000 mg/500 mg Injection is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.
AlcoholZonamax ES 1000 mg/500 mg Injection may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
DrivingNot expected to affect your ability to drive.
KidneyThere is limited information available on the use of Zonamax ES 1000 mg/500 mg Injection in patients with kidney disease. Please consult your doctor.
LiverThere is limited information available on the use of Zonamax ES 1000 mg/500 mg Injection in patients with liver disease. Please consult your doctor.
Habit formingNo

Warnings and precautions

Finish the whole course even after you feel better. Stopping early lets the strongest bacteria survive, and they are the ones that come back resistant. Stop and seek emergency care for swelling of the face or throat, difficulty breathing, or a widespread rash — a penicillin allergy can be serious. Tell every doctor and pharmacist if you have ever reacted to penicillin. Tell your doctor if loose motions become severe or watery, or continue after the course — this needs attention rather than an anti-diarrhoeal. Antibiotics do not work against colds, flu or most sore throats, which are caused by viruses. Finish the whole course even after you feel better — stopping early breeds resistant bacteria. Tell your doctor if you have ever had a severe reaction to penicillin; a small proportion of people react to both groups. Report severe or watery loose motions during or after the course rather than treating them yourself. Several medicines in this group are on Schedule H1 precisely because overuse drives antibiotic resistance. Take it only when a doctor has prescribed it for you.

Do not take Zonamax Es if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for anyone with a known penicillin allergy. Not for anyone with a known allergy to cephalosporin antibiotics.

Interactions with other medicines

May reduce the reliability of the oral contraceptive pill if you have vomiting or loose motions — use additional precautions during the course. Tell your doctor if you take methotrexate or a blood thinner. Antacids, iron and zinc reduce absorption — separate them by a couple of hours. Tell your doctor if you take a blood thinner.

How to store Zonamax Es

Store as printed on the carton — some injections need refrigeration and must not be frozen. Keep out of the reach of children.

Expert advice for Zonamax Es

<div class="style__desktop-container___1hcBT"><div class="style__desktop-video___2GTR9"><div class="styles__video-img___1rCzR"><div class=""/><div class=""/></div></div><div><div><div><div><div class="ExpertAdviceItem__content___1Djk2"><ul><li>You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance. </li> <li>Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.</li> <li>Diarrhea may occur as a side effect. Taking probiotics along with Zosul 1.5gm Injection may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.</li> <li>Stop taking Zosul 1.5gm Injection and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.</li></ul></div></div></div></div></div></div>

Manufacturer and class

Manufacturer:
MACLEODS PHARMACEUTICALS LTD
Therapeutic class:
Antibiotic
Drug class:
Penicillin and Cephalosporin

Substitutes for Zonamax Es

Medicines with the same active ingredient (Sulbactam (500mg) + Cefoperazone (1000mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Zonamax Es
Izone-S InjectionEYSYS PHARMAinjection · VIAL₹26447% more
Lactagard 1500 InjectionIPCA LABORATORIES LTD`injection · 1`S₹33889% more
Zofactum 1.5 g Injection1*20₹454153% more
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Zonamax Es FAQs

What is Zonamax Es used for?
Zonamax Es is commonly used for Zonamax ES 1000 mg/500 mg Injection is used in the treatment of bacterial infections. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Zonamax Es?
Zonamax Es contains Sulbactam (500mg) + Cefoperazone (1000mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How does Zonamax Es work?
Zonamax ES 1000 mg/500 mg Injection is a combination of two medicines: Cefoperazone and Sulbactam.
Is Zonamax Es a prescription medicine?
Yes. Zonamax Es is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Zonamax Es?
The side effects reported most often with Zonamax Es are Diarrhea Altered liver function test Allergic reaction Anemia (low number of red blood cells). Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Zonamax Es be taken during pregnancy?
Zonamax ES 1000 mg/500 mg Injection is probably safe to use during pregnancy.<br>Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Zonamax Es.
Can I drink alcohol while taking Zonamax Es?
Zonamax ES 1000 mg/500 mg Injection may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
Is Zonamax Es habit forming?
No. Zonamax Es is not known to be habit forming when taken as prescribed.
How much does Zonamax Es cost on PingMeDoc Pharmacy?
Zonamax Es starts at ₹179 (MRP ₹188) on PingMeDoc Pharmacy. Available in vial VIAL. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Zonamax Es?
Zonamax Es is manufactured by MACLEODS PHARMACEUTICALS LTD. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Zonamax Es delivered?
Zonamax Es is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Zonamax Es, Quick facts

Salt
Sulbactam (500mg) + Cefoperazone (1000mg)
Form
vial
Best price
₹179
MRP
₹188
Prescription
Required (Rx)
Schedule
Schedule H1
Brand
Macleods Pharmaceuticals Pvt Ltd
Manufacturer
MACLEODS PHARMACEUTICALS LTD
Therapeutic class
Antibiotic
Drug class
Penicillin and Cephalosporin
Habit forming
No
Variants
vial VIAL
Delivery
Standard across India

References

The information on Zonamax Es is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Zonamax Es.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.