Zoryl M 3

Composition of Zoryl M 3

Zoryl M 3 contains Glimepiride + Metformin. It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Zoryl M 3

Type 2 diabetes mellitus: to improve blood sugar control in adults when diet and exercise alone (or single medicine) are not enough.

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity
• Helps reduce liver glucose production
• Convenient combination therapy for type 2 diabetes

How Zoryl M 3 works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and helps the body use insulin better. Metformin (a biguanide) decreases glucose production in the liver and reduces glucose absorption while improving insulin sensitivity.

How to take Zoryl M 3

Take by mouth exactly as prescribed, usually once daily with/after the first main meal to reduce stomach upset. Swallow the tablet whole (do not crush/chew if SR). Monitor blood glucose regularly and follow diet/exercise advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Zoryl M 3mg/500mg Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zoryl M 3

Most side effects of Zoryl M are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• hypoglycaemia
• dizziness
• headache
• weight gain

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl M 3

Warnings and precautions

Risk of hypoglycaemia (especially with missed meals, heavy exercise, alcohol, elderly, kidney/liver impairment); metformin may rarely cause lactic acidosis—seek urgent care for rapid breathing, severe weakness, abdominal pain, or unusual sleepiness. Use caution/avoid in severe renal impairment; kidney function should be checked before and during therapy. Temporarily stop metformin before/after iodinated contrast procedures and during severe dehydration, serious infection, surgery, or hypoxia. Use with caution in hepatic disease; monitor for allergic reactions or blood disorders (rare).

Do not take Zoryl M if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases risk of hypoglycaemia/lactic acidosis),insulin or other antidiabetics (additive hypoglycaemia),beta-blockers (mask hypoglycaemia symptoms),ACE inhibitors (may enhance glucose-lowering),corticosteroids/thiazide diuretics/sympathomimetics (raise glucose),fluoroquinolones (glucose disturbances),azole antifungals and sulfonamides (may increase glimepiride effect),rifampicin (may reduce glimepiride effect),iodinated contrast media (lactic acidosis risk with metformin),cimetidine (may increase metformin levels)

How to store Zoryl M 3

Store below 25°C in a dry place, protected from moisture and light. Keep out of reach of children.

Expert advice for Zoryl M 3

You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Zoryl M 3mg/500mg Tablet PR. Take it with food to lower your chance of having an upset stomach. Monitor your blood sugar level regularly while you are taking this medicine. It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic. Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Zoryl M 3mg/500mg Tablet PR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide