Zoryl M D 1/1000 Tablet

Composition of Zoryl M D 1/1000 Tablet

Zoryl M D 1/1000 Tablet contains Glimepiride 1 mg + Metformin hydrochloride 1000 mg (modified release/extended release). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Zoryl M D 1/1000 Tablet

Type 2 diabetes mellitus in adults when diet and exercise alone or single-drug therapy does not provide adequate glycaemic control

Key benefits

• Lowers fasting and post‑meal blood sugar
• Improves insulin sensitivity
• Helps reduce HbA1c
• Convenient combination therapy

How Zoryl M D 1/1000 Tablet works

Glimepiride (a sulfonylurea) increases insulin release from pancreatic beta cells and improves peripheral glucose utilization. Metformin decreases hepatic glucose production and improves insulin sensitivity, reducing intestinal glucose absorption. The combination lowers fasting and post‑meal blood glucose.

How to take Zoryl M D 1/1000 Tablet

Take by mouth as prescribed, usually once daily with the first main meal (or as advised). Swallow tablet whole; do not crush or chew (MR/ER). Follow diet and exercise advice; monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zoryl M D 1/1000 Tablet

Most side effects of Zoryl M D 1/1000 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• weight gain

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl M D 1/1000 Tablet

Warnings and precautions

Risk of hypoglycaemia (higher with missed meals, alcohol, strenuous exercise, elderly); carry glucose source. Metformin may rarely cause lactic acidosis—avoid in severe kidney impairment, severe dehydration, sepsis, hypoxia, or severe liver disease; assess eGFR before and during therapy. Temporarily stop metformin before/after iodinated contrast procedures and major surgery as advised. Use caution in heart failure and in people with vitamin B12 deficiency (long‑term metformin can lower B12). Do not use in type 1 diabetes or diabetic ketoacidosis.

Do not take Zoryl M D 1/1000 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases hypoglycaemia and lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia), ACE inhibitors (may enhance glucose-lowering), corticosteroids/thiazide diuretics/thyroid hormones (raise glucose), rifampicin (may reduce effect), azole antifungals and macrolides (may increase sulfonylurea effect), fluoroquinolones (glucose disturbances), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (raises metformin levels)

How to store Zoryl M D 1/1000 Tablet

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Expert advice for Zoryl M D 1/1000 Tablet

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide