Zoryl Mp-2

Composition of Zoryl Mp-2

Zoryl Mp-2 contains Glimepiride 2 mg + Metformin Hydrochloride 500 mg (Sustained Release) + Pioglitazone 15 mg (tablet). It belongs to the Sulfonylurea + Biguanide + Thiazolidinedione (PPAR-gamma agonist) class of medicines.

Uses of Zoryl Mp-2

Type 2 diabetes mellitus in adults (when diet and exercise alone or dual therapy is not adequate) to improve blood glucose control

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity
• Helps reduce HbA1c
• Triple-action control for type 2 diabetes

How Zoryl Mp-2 works

Glimepiride (sulfonylurea) increases insulin release from pancreatic beta cells. Metformin SR reduces glucose production in the liver and improves insulin sensitivity. Pioglitazone (PPAR-gamma agonist) increases insulin sensitivity in muscle and fat, improving glucose uptake.

How to take Zoryl Mp-2

Take by mouth as prescribed, usually once daily with the first main meal. Swallow whole; do not crush or chew (SR tablet). Monitor blood glucose regularly and follow diet/exercise advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar and marked stomach upset. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zoryl Mp-2

Most side effects of Zoryl Mp-2 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal discomfort
• flatulence
• headache
• dizziness
• weight gain
• oedema (swelling)
• upper respiratory tract infection

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl Mp-2

Warnings and precautions

Risk of hypoglycaemia (especially with missed meals, alcohol, or increased exercise); carry glucose. Metformin: rare risk of lactic acidosis—avoid in severe kidney impairment, severe dehydration, sepsis, hypoxia; stop temporarily before/after iodinated contrast or major surgery as advised. Pioglitazone: can cause fluid retention and worsen heart failure; not recommended in NYHA III/IV heart failure; monitor for weight gain/oedema and breathlessness. Possible increased fracture risk; monitor for visual changes (macular oedema). Avoid/use caution in liver disease; periodic liver function tests. Not for type 1 diabetes or diabetic ketoacidosis.

Do not take Zoryl Mp-2 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for people with heart failure, active bladder cancer or unexplained blood in the urine.

Interactions with other medicines

Alcohol (increases hypoglycaemia and lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids and thiazide/loop diuretics (raise glucose), rifampicin (reduces pioglitazone effect), gemfibrozil (increases pioglitazone levels), miconazole/fluconazole (increase sulfonylurea effect), ACE inhibitors (may enhance glucose-lowering), iodinated contrast media (metformin—lactic acidosis risk), cationic drugs eliminated by renal tubular secretion e.g., cimetidine (increase metformin levels)

How to store Zoryl Mp-2

Store below 25°C, protect from moisture and light, keep in original strip/container. Keep out of reach of children.

Expert advice for Zoryl Mp-2

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them. Take it with the first mouthful of your meal so it can act on that meal. Expect some wind in the first weeks; it usually settles.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide + Thiazolidinedione (PPAR-gamma agonist)