Zoryl Ms Ir 2/500 mg Tablet

Composition of Zoryl Ms Ir 2/500 mg Tablet

Zoryl Ms Ir 2/500 mg Tablet contains Sitagliptin (50mg) + Glimepiride (2mg) + Metformin (1000mg). It belongs to the Sulfonylurea + Biguanide (combination) class of medicines.

Uses of Zoryl Ms Ir 2/500 mg Tablet

Type 2 diabetes mellitus in adults when diet and exercise alone or monotherapy is insufficient; helps control blood glucose and HbA1c.

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves HbA1c control
• Combines insulin release with reduced hepatic glucose production
• May reduce insulin resistance
• Convenient combination therapy for type 2 diabetes

How Zoryl Ms Ir 2/500 mg Tablet works

Glimepiride (a sulfonylurea) stimulates the pancreas to release insulin and improves insulin sensitivity. Metformin (a biguanide) reduces glucose production in the liver and improves peripheral glucose uptake, lowering blood sugar without usually causing hypoglycaemia on its own.

How to take Zoryl Ms Ir 2/500 mg Tablet

Oral tablet. Take exactly as prescribed, usually once or twice daily with meals to reduce stomach upset. Swallow whole with water; do not skip meals. Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Zoryl MS 50mg/2mg/1000mg Tablet IR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

Taking more Zoryl Ms Ir 2/500 mg than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zoryl Ms Ir 2/500 mg Tablet

Most side effects of Zoryl Ms Ir 2/500 mg are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• dizziness
• headache
• weight gain

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl Ms Ir 2/500 mg Tablet

Warnings and precautions

Risk of hypoglycaemia (higher with missed meals, alcohol, heavy exercise, elderly, kidney/liver impairment). Metformin rarely can cause lactic acidosis—seek urgent care for fast breathing, severe weakness, abdominal pain, or unusual sleepiness. Use with caution/avoid in severe renal impairment, severe hepatic disease, dehydration, severe infection, shock, or hypoxia; temporarily stop before/after iodinated contrast or major surgery as advised. Check kidney function periodically; long-term metformin may cause vitamin B12 deficiency. Not for type 1 diabetes or diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases hypoglycaemia/lactic acidosis risk), iodinated contrast media, insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia), corticosteroids/thiazides/sympathomimetics (raise glucose), ACE inhibitors (may increase hypoglycaemia), NSAIDs/salicylates (may increase hypoglycaemia), diuretics, cimetidine (may increase metformin levels), certain antibiotics (e.g., sulfonamides/fluoroquinolones may affect glucose)

How to store Zoryl Ms Ir 2/500 mg Tablet

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Expert advice for Zoryl Ms Ir 2/500 mg Tablet

Prefer taking Zoryl MS 50mg/2mg/1000mg Tablet IR after a meal or with a snack, as this will reduce the chance of an upset stomach. Zoryl MS 50mg/2mg/1000mg Tablet IR may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia (low blood sugar) symptoms, such as fatigue, dizziness, cold sweats, tremor, and anxiety. If you get unusually thirsty, pass urine more frequently, and feel tired, let your doctor know. These are signs that there is too much sugar in your blood and your dose may need adjusting. Monitor your blood sugar regularly while taking this medicine. Lifestyle changes like low sugar diet, exercising, losing weight, not smoking, and cutting down on alcohol intake may help this medication work better.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide (combination)