Zucator M 1000 mg Tablet

Composition of Zucator M 1000 mg Tablet

Zucator M 1000 mg Tablet contains Sitagliptin 50 mg + Metformin (as Metformin Hydrochloride) 1000 mg tablets. It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Zucator M 1000 mg Tablet

• Type 2 diabetes mellitus: to improve blood glucose control as an adjunct to diet and exercise
• when dual therapy is appropriate

Key benefits

• Helps control fasting and post-meal blood sugar
• Improves insulin sensitivity and reduces liver glucose output
• Lowers glucagon and supports glucose-dependent insulin secretion
• May aid in achieving HbA1c targets with lifestyle measures

How Zucator M 1000 mg Tablet works

Metformin reduces glucose production in the liver and improves insulin sensitivity in muscles. Sitagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), enhancing glucose-dependent insulin release and reducing glucagon, thereby lowering blood sugar with low risk of hypoglycaemia when used without insulin/secretagogues.

How to take Zucator M 1000 mg Tablet

Oral tablets; take exactly as prescribed, usually with meals to reduce stomach upset. Swallow whole with water; do not crush/chew if it is a modified-release form (confirm pack). Maintain diet and exercise; monitor blood glucose as advised.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zucator M as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zucator M than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zucator M 1000 mg Tablet

Most side effects of Zucator M are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• upper respiratory tract infection
• nasopharyngitis
• dizziness

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zucator M 1000 mg Tablet

Warnings and precautions

Prescription-only antidiabetic. Risk of lactic acidosis with metformin (seek urgent care for fast breathing, severe weakness, abdominal pain, drowsiness). Avoid/use with caution in kidney impairment; assess eGFR before start and periodically—contraindicated in severe renal impairment. Temporarily stop before iodinated contrast studies or major surgery as advised. Sitagliptin: rare pancreatitis (severe persistent abdominal pain), hypersensitivity reactions, bullous pemphigoid; dose adjustment needed in renal impairment. Monitor vitamin B12 with long-term metformin use. Hypoglycaemia risk increases if combined with insulin or sulfonylureas.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cationic drugs affecting renal tubular secretion (e.g., cimetidine), insulin and sulfonylureas (increased hypoglycaemia), ACE inhibitors/ARBs and diuretics (renal function changes), digoxin (sitagliptin may slightly increase levels)

How to store Zucator M 1000 mg Tablet

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Manufacturer and class

Manufacturer:

TORRENT PHARMACEUTICALS

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide