Zycolchin Tablet

Composition of Zycolchin Tablet

Zycolchin Tablet contains Colchicine 0.5 mg tablet. It belongs to the Antimitotic/anti-inflammatory (colchicine; microtubule inhibitor) class of medicines.

Uses of Zycolchin Tablet

Prevention and treatment of acute gout attacks; prophylaxis of gout flares when starting urate-lowering therapy. Also used in some cases for familial Mediterranean fever as prescribed.

Key benefits

• Relieves pain and swelling in acute gout
• Reduces inflammation due to urate crystals
• Helps prevent recurrent gout flares
• Useful as flare prophylaxis when starting urate-lowering therapy

How Zycolchin Tablet works

Colchicine reduces inflammation by inhibiting microtubule formation and neutrophil activity at sites of urate crystal deposition. This decreases inflammatory mediator release and pain/swelling during gout flares.

How to take Zycolchin Tablet

Take as directed by a doctor. Swallow tablet with water, with or without food (take with food if stomach upset occurs). For gout flare: dosing is doctor-specific; do not exceed prescribed dose. For prophylaxis: take at the same time daily.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zycolchin as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zycolchin than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zycolchin Tablet

Most side effects of Zycolchin are mild and settle as the body adjusts. Reported side effects include:

• Diarrhoea
• nausea
• vomiting
• abdominal pain/cramps
• loss of appetite

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zycolchin Tablet

Warnings and precautions

Use only on prescription; narrow therapeutic index. Do not use in severe kidney or liver impairment, or with strong CYP3A4/P-gp inhibitors due to risk of life-threatening toxicity. Stop and seek medical help if severe diarrhoea/vomiting, muscle pain/weakness, numbness/tingling, unusual bleeding/bruising, fever, or signs of infection occur. Use caution in elderly and in renal/hepatic disease; dose adjustment may be needed. Avoid grapefruit/grapefruit juice.

Interactions with other medicines

Strong CYP3A4/P-gp inhibitors (clarithromycin, erythromycin, ketoconazole/itraconazole, ritonavir/cobicistat, cyclosporine, verapamil/diltiazem) increase toxicity risk; statins/fibrates increase myopathy risk; digoxin may increase toxicity risk; other myelosuppressive drugs increase blood disorder risk; grapefruit juice increases levels

How to store Zycolchin Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Manufacturer and class

Manufacturer:

ZYDUS HEALTHCARE PHARMA

Therapeutic class:

Antigout

Drug class:

Antimitotic/anti-inflammatory (colchicine; microtubule inhibitor)