Zycolchin Tab 10S

Composition

Colchicine 0.5 mg tablet

Uses of Zycolchin Tab 10S

Prevention and treatment of acute gout attacks; prophylaxis of gout flares when starting urate-lowering therapy. Also used in some cases for familial Mediterranean fever as prescribed.

• •Relieves pain and swelling in acute gout
• •Reduces inflammation due to urate crystals
• •Helps prevent recurrent gout flares
• •Useful as flare prophylaxis when starting urate-lowering therapy

How it works

Colchicine reduces inflammation by inhibiting microtubule formation and neutrophil activity at sites of urate crystal deposition. This decreases inflammatory mediator release and pain/swelling during gout flares.

Directions for use

Take as directed by a doctor. Swallow tablet with water, with or without food (take with food if stomach upset occurs). For gout flare: dosing is doctor-specific; do not exceed prescribed dose. For prophylaxis: take at the same time daily.

Side effects

Common side effects of Zycolchin Tab 10S may include:

• •Diarrhoea
• •nausea
• •vomiting
• •abdominal pain/cramps
• •loss of appetite

Warnings & precautions

Use only on prescription; narrow therapeutic index. Do not use in severe kidney or liver impairment, or with strong CYP3A4/P-gp inhibitors due to risk of life-threatening toxicity. Stop and seek medical help if severe diarrhoea/vomiting, muscle pain/weakness, numbness/tingling, unusual bleeding/bruising, fever, or signs of infection occur. Use caution in elderly and in renal/hepatic disease; dose adjustment may be needed. Avoid grapefruit/grapefruit juice.