Zyloric 300 Tablet

Composition of Zyloric 300 Tablet

Zyloric 300 Tablet contains Allopurinol (300mg). It belongs to the Xanthine oxidase inhibitor class of medicines.

Uses of Zyloric 300 Tablet

• Treatment and prevention of gout (chronic hyperuricaemia)
• prevention of uric acid kidney stones
• prevention/treatment of high uric acid due to cancer chemotherapy (tumour lysis syndrome)

Key benefits

• Lowers high uric acid levels
• Prevents recurrent gout attacks over time
• Helps dissolve/prevent urate crystal deposits (tophi)
• Prevents uric acid kidney stones
• Helps manage hyperuricaemia during chemotherapy

How Zyloric 300 Tablet works

Allopurinol inhibits xanthine oxidase, an enzyme required for conversion of hypoxanthine and xanthine to uric acid. This lowers serum and urinary uric acid levels and helps prevent urate crystal formation and deposits in joints/kidneys.

How to take Zyloric 300 Tablet

Tablet for oral use. Take exactly as prescribed, preferably after food and with plenty of water. Continue long term; do not stop abruptly. Dose may be started low and titrated; ensure good hydration. If a dose is missed, take it when remembered unless it is close to the next dose.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can seriously suppress the bone marrow and damage the liver. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zyloric 300 Tablet

Most side effects of Zyloric are mild and settle as the body adjusts. Reported side effects include:

• Skin rash
• nausea
• vomiting
• diarrhoea
• abdominal pain
• headache
• dizziness
• drowsiness
• taste changes
• elevated liver enzymes

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zyloric 300 Tablet

Warnings and precautions

Do not use if allergic to allopurinol. Stop and seek urgent medical help if rash, fever, sore throat, mouth ulcers, facial swelling, or peeling skin occurs (risk of severe cutaneous adverse reactions including SJS/TEN/DRESS). Use with caution in kidney or liver disease; dose adjustment may be required and monitoring advised. May precipitate an acute gout attack when started—doctor may prescribe prophylaxis (e.g., colchicine/NSAID). Maintain adequate fluid intake; monitor uric acid. Risk of hypersensitivity is higher in renal impairment and with thiazide diuretics; HLA-B*58:01 testing may be considered in high-risk ethnic groups.

Do not take Zyloric if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with an active serious infection, or with severe liver or bone-marrow disease. Several of these medicines must not be used in pregnancy.

Interactions with other medicines

Azathioprine, mercaptopurine (require major dose reduction/avoid), warfarin (may increase effect), theophylline, didanosine, cyclophosphamide/chlorpropamide (increased toxicity risk), ampicillin/amoxicillin (increased rash risk), thiazide diuretics (increased hypersensitivity risk), ACE inhibitors (reported increased hypersensitivity), probenecid/uricosurics (may alter levels)

How to store Zyloric 300 Tablet

Store at room temperature (below 25°C), protected from moisture and light. Keep in original pack and out of reach of children.

Expert advice for Zyloric 300 Tablet

<div class="style__desktop-container___1hcBT"><div class="style__desktop-video___2GTR9"><div class="styles__video-img___1rCzR"><div class=""/><div class=""/></div></div><div><div><div><div><div class="ExpertAdviceItem__content___1Djk2"><ul><li>Your doctor has prescribed Zyloric 300 Tablet to reduce episodes of gout attack.</li> <li>Take Zyloric 300 Tablet at the same time every day, with or without food.</li> <li>Take plenty of fluids (2-3 litres) daily while on Zyloric 300 Tablet .</li> <li>Notify your doctor if you develop a rash. This could be a sign of allergy and should go away on discontinuing Zyloric 300 Tablet .</li> <li>When you first start taking Zyloric 300 Tablet , you might have more gout attacks. Do not stop Zyloric 300 Tablet on having an acute attack of gout as that could make an attack worse.</li> <li>Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.</li> <li>Do not consume alcohol while taking Zyloric 300 Tablet as it may cause your gout to flare up.</li></ul></div></div></div></div></div></div>

Manufacturer and class

Manufacturer:

GLAXO SMITHKLINE PHARMA

Therapeutic class:

prescription

Drug class:

Xanthine oxidase inhibitor