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Treatment of progesterone deficiency states such as irregular/absent periods (secondary amenorrhoea), abnormal uterine bleeding due to hormonal imbalance, dysmenorrhoea, endometriosis, premenstrual syndrome (PMS), infertility due to luteal phase defect, threatened or recurrent miscarriage due to luteal insufficiency; used as part of hormone replacement therapy (HRT) with estrogen to protect the endometrium

Dydrogesterone is a synthetic progestogen that mimics the action of natural progesterone. It transforms the endometrium into the secretory phase, stabilizes the uterine lining, and supports implantation and maintenance of pregnancy in luteal insufficiency.

Oral tablet. Take exactly as prescribed by the doctor; dosing depends on indication and menstrual cycle day. Can be taken with or without food; take at the same time each day and swallow with water. Do not stop abruptly without medical advice.

Headache, nausea, abdominal pain/bloating, breast tenderness, dizziness, drowsiness, spotting/breakthrough bleeding, mood changes, vomiting

Use only under medical supervision. Inform doctor if you have liver disease, history of blood clots/thromboembolism, unexplained vaginal bleeding, hormone-dependent cancers (breast/uterine), depression, or porphyria. Seek urgent care for symptoms of thrombosis (leg swelling/pain, chest pain, shortness of breath), severe headache/visual changes, or jaundice. In HRT use, regular breast and gynecologic check-ups are advised.

Enzyme inducers may reduce effect (rifampicin, rifabutin, carbamazepine, phenytoin, phenobarbital, primidone, topiramate, St John’s wort). Some antiretrovirals and antifungals may alter hormone levels; inform doctor about all medicines.

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack. Keep out of reach of children.

Duphaston 10 mg Tablet, Dydrogesterone 10 mg Tablet (generic), Dydrolux 10 mg Tablet, Dydrosure 10 mg Tablet, Dydrowin 10 mg Tablet