Insugen-50/50 Refil

Human insulin (100IU)

Diabetes mellitus (Type 1 and Type 2) requiring insulin therapy; control of blood glucose with a premixed insulin regimen

This is a premixed human insulin containing a rapid-acting soluble fraction and an intermediate-acting NPH fraction. It lowers blood glucose by increasing peripheral glucose uptake (muscle/fat) and reducing hepatic glucose production, providing both meal-time and basal insulin coverage.

For subcutaneous use only via compatible reusable insulin pen for 3 mL cartridges (refill). Dose and timing as prescribed; commonly given 1–2 times daily about 30 minutes before meals. Gently roll/tilt cartridge to resuspend until uniformly cloudy; do not use if clumpy or separated. Rotate injection sites; monitor blood glucose regularly.

Hypoglycaemia, injection site reactions (pain/redness/swelling/itching), weight gain, lipodystrophy (lumps or dents at injection site), oedema, rash

Risk of severe hypoglycaemia—carry glucose and recognize symptoms; avoid driving/operating machinery if low sugar risk. Do not use during hypoglycaemia. Adjust dose with changes in diet, exercise, illness, stress, or renal/hepatic impairment. Rotate sites to reduce lipodystrophy. Use only as prescribed; do not share pens/needles. Seek urgent help for signs of allergy (wheezing, swelling, generalized rash) or recurrent severe lows.

Other antidiabetics, alcohol, ACE inhibitors/ARBs, salicylates, MAO inhibitors may increase hypoglycaemic effect; corticosteroids, thiazide diuretics, sympathomimetics, thyroid hormones, oral contraceptives may reduce insulin effect; beta-blockers can mask hypoglycaemia symptoms; atypical antipsychotics can affect glucose; pioglitazone with insulin may increase risk of fluid retention/heart failure.

Store unopened cartridges refrigerated at 2–8°C; do not freeze. Keep away from direct heat/light. Once in use, keep at room temperature (as per pack insert, typically below 25–30°C) and use within the in-use period; keep cartridge in pen with cap on.

Huminsulin 50/50 Cartridge, Actrapid 50/50 (premix) (where available), Mixtard 50 Penfill (where available), Insuman Comb 50 Penfill (where available), Gensulin M50 Cartridge (where available)