Zita Pio Met 500 Tab 10S

Tablet

Type 2 diabetes mellitus—adjunct to diet and exercise to improve glycaemic control in adults when single/dual therapy is inadequate.

Metformin decreases hepatic glucose production and improves peripheral insulin sensitivity. Sitagliptin (a DPP-4 inhibitor) increases incretin levels, enhancing glucose-dependent insulin release and reducing glucagon. Pioglitazone (a thiazolidinedione) improves insulin sensitivity in muscle and adipose tissue.

Tablet for oral use. Take exactly as prescribed, usually with meals to reduce stomach upset. Swallow whole with water; do not crush/chew. Regularly monitor blood glucose/HbA1c as advised.

nausea, diarrhoea, abdominal discomfort, headache, upper respiratory tract infection, dizziness, weight gain, oedema (swelling), hypoglycaemia (especially with other antidiabetics), increased risk of fractures

Prescription-only antidiabetic. Metformin: risk of lactic acidosis—avoid in severe renal impairment; assess kidney function before and during therapy; temporarily stop before/after iodinated contrast or major surgery as advised. Pioglitazone: may cause/worsen heart failure due to fluid retention—contraindicated in NYHA class III/IV; monitor for rapid weight gain, oedema, breathlessness; may increase fracture risk; monitor liver enzymes. Sitagliptin: rare pancreatitis/hypersensitivity—seek care for severe abdominal pain or rash. Use caution in elderly, dehydration, liver disease; maintain diet/exercise.

Alcohol (increases lactic acidosis risk), iodinated contrast media, insulin/sulfonylureas (increased hypoglycaemia), diuretics/corticosteroids/sympathomimetics (may worsen glycaemic control), gemfibrozil (increases pioglitazone levels), rifampicin (reduces pioglitazone levels), digoxin (levels may increase with pioglitazone), carbonic anhydrase inhibitors like topiramate (may increase acidosis risk with metformin).

Store below 25°C in a dry place. Protect from moisture and light. Keep out of reach of children.

Janumet 50/500 Tablet, Istamet 50/500 Tablet, Sitacure M 50/500 Tablet, Zita Met 50/500 Tablet, Galvus Met 50/500 Tablet