Avozosin-T 2.5 mg Tablet

Composition of Avozosin-T 2.5 mg Tablet

Avozosin-T 2.5 mg Tablet contains Tofacitinib 2.5 mg (as tofacitinib citrate). It belongs to the Janus kinase (JAK) inhibitor class of medicines.

Uses of Avozosin-T 2.5 mg Tablet

• Treatment of autoimmune inflammatory conditions such as rheumatoid arthritis
• psoriatic arthritis and ulcerative colitis (as prescribed by specialist); may also be used for other immune-mediated diseases per doctor’s advice

Key benefits

• Reduces joint pain and swelling
• Improves physical function in inflammatory arthritis
• Helps control immune-mediated inflammation
• Can reduce flare-ups in chronic autoimmune disease

How Avozosin-T 2.5 mg Tablet works

Tofacitinib is a Janus kinase (JAK) inhibitor. It blocks JAK1/JAK3 signaling pathways involved in cytokine activity, thereby reducing immune overactivity, inflammation, pain and tissue damage.

How to take Avozosin-T 2.5 mg Tablet

Tablet for oral use. Take exactly as prescribed, at the same time each day, with or without food. Do not stop abruptly without medical advice; if you miss a dose, take it when remembered unless it is close to the next dose.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Avozosin-T as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Avozosin-T than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Avozosin-T 2.5 mg Tablet

Most side effects of Avozosin-T are mild and settle as the body adjusts. Reported side effects include:

• Upper respiratory tract infection
• headache
• diarrhea
• nausea
• abdominal pain
• raised liver enzymes
• increased cholesterol
• rash
• herpes zoster (shingles)

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Avozosin-T 2.5 mg Tablet

Warnings and precautions

Prescription-only immunosuppressant. Increases risk of serious infections (TB, fungal, bacterial, viral); screening for TB/hepatitis may be required before and during therapy. Risk of herpes zoster, blood clots (DVT/PE), major cardiovascular events and certain malignancies may be increased in some patients; seek urgent care for chest pain, breathlessness, unilateral leg swelling, severe abdominal pain. Monitor CBC, liver function and lipids as advised; may cause low blood counts. Avoid live vaccines during treatment; keep vaccinations up to date prior to starting. Use caution in liver/kidney impairment; dose adjustments may be needed.

Interactions with other medicines

Strong CYP3A4 inhibitors (ketoconazole, clarithromycin), strong CYP3A4 inducers (rifampicin, carbamazepine, phenytoin), other immunosuppressants/biologics (azathioprine, cyclosporine, tacrolimus, TNF inhibitors), live vaccines

How to store Avozosin-T 2.5 mg Tablet

Store below 25°C in a cool, dry place away from light and moisture. Keep in original blister and out of reach of children.

Manufacturer and class

Manufacturer:

MICRO LABS

Therapeutic class:

Immunosuppressant / Anti-rheumatic (DMARD)

Drug class:

Janus kinase (JAK) inhibitor