
8X Cream
Cipla Limited - Cream - 30 G
Prescription required
Divalproex (250mg)
Depakote 250 mg Tablet is used for mania Migraine Treatment of Bipolar disorder Trigeminal neuralgia Treatment of Epilepsy/Seizures Seizures Epilepsy.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Depakote 250 mg Tablet contains Divalproex (250mg). It belongs to the Anticonvulsant class of medicines.
Mania Migraine Treatment of Bipolar disorder Trigeminal neuralgia Treatment of Epilepsy/Seizures Seizures Epilepsy
Depakote 250 Tablet is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depakote 250 Tablet may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Depakote 250 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause deep unconsciousness, slowed breathing and dangerous heart rhythm disturbance. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Depakote are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Depakote 250 Tablet is highly unsafe to use during pregnancy.<br>Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor. |
|---|---|
| Breastfeeding | Depakote 250 Tablet is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby. |
| Alcohol | Depakote 250 Tablet may cause excessive drowsiness and calmness with alcohol. |
| Driving | Driving UNSAFE |
| Kidney | Depakote 250 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Depakote 250 Tablet may not be needed in these patients. Please consult your doctor. |
| Liver | Depakote 250 Tablet should be used with caution in patients with liver disease. Dose adjustment of Depakote 250 Tablet may be needed. Please consult your doctor. |
| Habit forming | No |
Never stop or change an anti-epileptic on your own. Stopping abruptly can cause prolonged, dangerous seizures. Sodium valproate and divalproex must not be used by anyone who is pregnant or could become pregnant unless a specialist has confirmed there is no alternative — they cause serious birth defects and developmental problems. Effective contraception is essential. Seek urgent care for any rash, especially in the first weeks — a rash with fever, blistering or peeling can be life-threatening. Report yellowing of the eyes or skin, persistent vomiting, unusual bruising or severe tiredness at once. Tell your doctor about any change in mood or any thoughts of harming yourself. Take the same brand each time unless your neurologist has agreed to a change; switching can alter seizure control.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Valproate-containing medicines are contraindicated in pregnancy for epilepsy unless no alternative exists, and in all women of childbearing potential without a pregnancy prevention programme. Several are not suitable in significant liver disease.
This group interacts very widely, including with contraceptives, blood thinners and other anti-epileptics. Give your doctor a full list of what you take. Hormonal contraception may become unreliable — ask your doctor which method to use.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Take your medication regularly as directed by your doctor, as missing doses can trigger seizures. Take it at the same time every day to maintain consistent levels in your body. It can be taken with or without food; however, consider taking it with food to avoid an upset stomach. Do not change the brand of your medicine, and make sure that you have a sufficient amount of medicine present with you. It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. Monitor your weight during treatment with this medicine, as it can cause weight gain. Your doctor may get regular blood tests done to monitor how the medication is affecting your body. Inform your doctor if you notice yellowing of the eyes or skin, dark urine, or stomach pain. Avoid consuming alcohol when taking Depakote 250 Tablet, as it may cause excessive sleepiness or drowsiness. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Do not take Depakote 250 Tablet if you are pregnant or planning to conceive or breastfeed.
Medicines with the same active ingredient (Divalproex (250mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Depakote 250 mg Tablet |
|---|---|---|---|
| Divalid-ER 250 mgLINUX LABORATORIES` | 10`S | ₹94 | 58% cheaper |
| Trend XR 250 mg TabletTorrent Pharmaceuticals Ltd | tablet · 10`S | ₹118 | 47% cheaper |
| Divaa-OD 250 mg TabletIntas Pharmaceuticals Ltd | tablet · 15`S | ₹181 | 19% cheaper |
| Divalid-ER 500 mgLINUX LABORATORIES` | 10`S | ₹182 | 19% cheaper |

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The information on Depakote 250 mg Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.