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Prescription requiredCipla LimitedNEURO CNS

Depakote 250 mg Tablet

Divalproex (250mg)

Depakote 250 mg Tablet is used for mania Migraine Treatment of Bipolar disorder Trigeminal neuralgia Treatment of Epilepsy/Seizures Seizures Epilepsy.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

₹224
Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Divalproex (250mg)
Available variants: tablet 250 mg 15
Best price: ₹224
Prescription: Required
Manufacturer: CIPLA LIMITED

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Depakote 250 mg Tablet

Depakote 250 mg Tablet contains Divalproex (250mg). It belongs to the Anticonvulsant class of medicines.

Uses of Depakote 250 mg Tablet

Mania Migraine Treatment of Bipolar disorder Trigeminal neuralgia Treatment of Epilepsy/Seizures Seizures Epilepsy

Key benefits

  • In Treatment of Bipolar disorder Depakote 250 Tablet works to restore the normal balance of nerve activity in your brain. It can help prevent extreme changes in mood and help you feel less agitated. You may experience fewer episodes of low mood. It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor advises you to. You should continue to eat well and keep fit to reduce symptoms of bipolar disorder. In Treatment of Epilepsy/Seizures Depakote 250 Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures
  • it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion
  • uncontrollable jerking movements
  • loss of awareness
  • and fear or anxiety. This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure. Show More

How Depakote 250 mg Tablet works

Depakote 250 Tablet is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

How to take Depakote 250 mg Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depakote 250 Tablet may be taken with or without food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Depakote 250 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause deep unconsciousness, slowed breathing and dangerous heart rhythm disturbance. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Depakote 250 mg Tablet

Most side effects of Depakote are mild and settle as the body adjusts. Reported side effects include:

  • Loss of appetite Nausea Vomiting Sleepiness Hair loss Weight gain Liver function abnormal Tremor

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Depakote 250 mg Tablet

PregnancyDepakote 250 Tablet is highly unsafe to use during pregnancy.<br>Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
BreastfeedingDepakote 250 Tablet is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.
AlcoholDepakote 250 Tablet may cause excessive drowsiness and calmness with alcohol.
DrivingDriving UNSAFE
KidneyDepakote 250 Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Depakote 250 Tablet may not be needed in these patients. Please consult your doctor.
LiverDepakote 250 Tablet should be used with caution in patients with liver disease. Dose adjustment of Depakote 250 Tablet may be needed. Please consult your doctor.
Habit formingNo

Warnings and precautions

Never stop or change an anti-epileptic on your own. Stopping abruptly can cause prolonged, dangerous seizures. Sodium valproate and divalproex must not be used by anyone who is pregnant or could become pregnant unless a specialist has confirmed there is no alternative — they cause serious birth defects and developmental problems. Effective contraception is essential. Seek urgent care for any rash, especially in the first weeks — a rash with fever, blistering or peeling can be life-threatening. Report yellowing of the eyes or skin, persistent vomiting, unusual bruising or severe tiredness at once. Tell your doctor about any change in mood or any thoughts of harming yourself. Take the same brand each time unless your neurologist has agreed to a change; switching can alter seizure control.

Do not take Depakote if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Valproate-containing medicines are contraindicated in pregnancy for epilepsy unless no alternative exists, and in all women of childbearing potential without a pregnancy prevention programme. Several are not suitable in significant liver disease.

Interactions with other medicines

This group interacts very widely, including with contraceptives, blood thinners and other anti-epileptics. Give your doctor a full list of what you take. Hormonal contraception may become unreliable — ask your doctor which method to use.

How to store Depakote 250 mg Tablet

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Depakote 250 mg Tablet

Take your medication regularly as directed by your doctor, as missing doses can trigger seizures. Take it at the same time every day to maintain consistent levels in your body. It can be taken with or without food; however, consider taking it with food to avoid an upset stomach. Do not change the brand of your medicine, and make sure that you have a sufficient amount of medicine present with you. It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. Monitor your weight during treatment with this medicine, as it can cause weight gain. Your doctor may get regular blood tests done to monitor how the medication is affecting your body. Inform your doctor if you notice yellowing of the eyes or skin, dark urine, or stomach pain. Avoid consuming alcohol when taking Depakote 250 Tablet, as it may cause excessive sleepiness or drowsiness. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Do not take Depakote 250 Tablet if you are pregnant or planning to conceive or breastfeed.

Manufacturer and class

Manufacturer:
CIPLA LIMITED
Therapeutic class:
NEURO CNS
Drug class:
Anticonvulsant
Chemical class:
Methyl- branched fatty acids

Substitutes for Depakote 250 mg Tablet

Medicines with the same active ingredient (Divalproex (250mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Depakote 250 mg Tablet
Divalid-ER 250 mgLINUX LABORATORIES`10`S₹9458% cheaper
Trend XR 250 mg TabletTorrent Pharmaceuticals Ltdtablet · 10`S₹11847% cheaper
Divaa-OD 250 mg TabletIntas Pharmaceuticals Ltdtablet · 15`S₹18119% cheaper
Divalid-ER 500 mgLINUX LABORATORIES`10`S₹18219% cheaper
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Depakote 250 mg Tablet FAQs

What is Depakote 250 mg Tablet used for?
Depakote 250 mg Tablet is commonly used for Mania Migraine Treatment of Bipolar disorder Trigeminal neuralgia Treatment of Epilepsy/Seizures Seizures Epilepsy. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Depakote 250 mg Tablet?
Depakote 250 mg Tablet contains Divalproex (250mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Depakote 250 mg Tablet?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Depakote 250 mg Tablet work?
Depakote 250 Tablet is an antiepileptic medication.
Is Depakote 250 mg Tablet a prescription medicine?
Yes. Depakote 250 mg Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Depakote 250 mg Tablet?
The side effects reported most often with Depakote are Loss of appetite Nausea Vomiting Sleepiness Hair loss Weight gain Liver function abnormal Tremor. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Depakote 250 mg Tablet be taken during pregnancy?
Depakote 250 Tablet is highly unsafe to use during pregnancy.<br>Human and animal studies have shown significant adverse effects on the foetus. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Depakote.
Can I drink alcohol while taking Depakote 250 mg Tablet?
Depakote 250 Tablet may cause excessive drowsiness and calmness with alcohol.
What if I miss a dose of Depakote 250 mg Tablet?
If you miss a dose of Depakote 250 Tablet, take it as soon as possible.
Is Depakote 250 mg Tablet habit forming?
No. Depakote 250 mg Tablet is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Depakote 250 mg Tablet?
Divalid-ER 250 mg has the same active ingredient and strength and is listed from ₹94 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Depakote 250 mg Tablet cost on PingMeDoc Pharmacy?
Depakote 250 mg Tablet starts at ₹224 on PingMeDoc Pharmacy. Available in tablet 250 mg 15. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Depakote 250 mg Tablet?
Depakote 250 mg Tablet is manufactured by CIPLA LIMITED. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Depakote 250 mg Tablet delivered?
Depakote 250 mg Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Depakote 250 mg Tablet, Quick facts

Salt
Divalproex (250mg)
Form
tablet
Best price
₹224
Prescription
Required (Rx)
Schedule
Schedule H
Brand
CIPLA LIMITED
Manufacturer
CIPLA LIMITED
Therapeutic class
NEURO CNS
Drug class
Anticonvulsant
Chemical class
Methyl- branched fatty acids
Action class
Sodium Channel Modulators- Antiepileptic drugs (AEDs)
Habit forming
No
Variants
tablet 250 mg 15
Delivery
Standard across India

References

The information on Depakote 250 mg Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Depakote 250 mg Tablet.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.