Eprisan D SR

Composition of Eprisan D SR

Eprisan D SR contains Esomeprazole 40 mg + Domperidone 30 mg (Sustained Release) capsule. It belongs to the Proton Pump Inhibitor (esomeprazole) + Prokinetic/Antiemetic (domperidone, D2 antagonist) class of medicines.

Uses of Eprisan D SR

• Gastroesophageal reflux disease (GERD)
• heartburn and acid reflux
• gastritis/acid-peptic symptoms
• nausea and vomiting associated with reflux or functional dyspepsia

Key benefits

• Relieves heartburn and acid reflux
• Reduces stomach acid and heals erosive esophagitis
• Improves gastric motility and reduces bloating
• Helps control nausea and vomiting

How Eprisan D SR works

Esomeprazole is a proton pump inhibitor that reduces stomach acid by blocking the H+/K+ ATPase pump in gastric parietal cells. Domperidone is a dopamine (D2) receptor antagonist that improves gastric motility and helps relieve nausea by enhancing gastric emptying and increasing lower esophageal sphincter tone.

How to take Eprisan D SR

Oral sustained-release capsule/tablet: usually taken once daily, preferably 30 minutes before food (often before breakfast) or as directed by a doctor. Swallow whole; do not crush or chew. Follow the prescribed duration.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine may cause confusion, blurred vision, sweating and a fast heartbeat. It can cause drowsiness, disorientation and abnormal muscle movements. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Eprisan D SR

Most side effects of Eprisan D SR are mild and settle as the body adjusts. Reported side effects include:

• Headache
• dizziness
• dry mouth
• abdominal pain
• diarrhea
• constipation
• flatulence
• nausea
• increased prolactin (breast tenderness/galactorrhea)
• rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Eprisan D SR

Warnings and precautions

Use with caution in liver disease (domperidone exposure may increase). Domperidone may cause QT prolongation/serious arrhythmias—avoid in patients with known QT prolongation, significant electrolyte disturbances, heart disease, or with other QT-prolonging drugs. Long-term PPI use may be associated with low magnesium, vitamin B12 deficiency, bone fracture risk and increased risk of gastrointestinal infections; use the lowest effective dose. Seek medical advice if alarm symptoms occur (blood in vomit/stool, weight loss, persistent vomiting, difficulty swallowing).

Do not take Eprisan D SR if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with bleeding, blockage or perforation of the gut, or with certain heart rhythm disorders.

Interactions with other medicines

QT-prolonging medicines (e.g., amiodarone, sotalol, quinolones, macrolides), strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir) may increase domperidone levels and cardiac risk; other acid-reducing agents; clopidogrel (reduced activation with some PPIs), warfarin (monitor INR), digoxin, methotrexate (high-dose), drugs needing acidic pH for absorption (e.g., ketoconazole, atazanavir).

How to store Eprisan D SR

Store below 25°C in a dry place, protected from moisture and direct light. Keep out of reach of children.

Expert advice for Eprisan D SR

Take it before breakfast, not after a meal. Eat smaller meals, avoid late dinners, raise the head of your bed and avoid smoking — these do as much as the tablet for reflux. Take it shortly before meals for bloating and early fullness. Sip fluids frequently in small amounts, and use oral rehydration salts if you have been vomiting.

Manufacturer and class

Manufacturer:

EISAI INDIA PVT LTD

Therapeutic class:

Antiulcer/Antireflux (Gastrointestinal)

Drug class:

Proton Pump Inhibitor (esomeprazole) + Prokinetic/Antiemetic (domperidone, D2 antagonist)