Neksium D 40/30 mg Capsule

Composition of Neksium D 40/30 mg Capsule

Neksium D 40/30 mg Capsule contains Domperidone (30mg) + Esomeprazole (40mg). It belongs to the Proton pump inhibitor (esomeprazole) + dopamine D2 antagonist prokinetic/antiemetic (domperidone) class of medicines.

Uses of Neksium D 40/30 mg Capsule

• Gastroesophageal reflux disease (GERD)
• acid reflux/heartburn
• gastritis and acidity with associated nausea/vomiting or bloating
• functional dyspepsia

Key benefits

• Relieves heartburn and acid reflux
• Reduces stomach acid and heals esophagitis
• Improves gastric emptying to reduce regurgitation/bloating
• Helps control nausea and vomiting associated with reflux/dyspepsia

How Neksium D 40/30 mg Capsule works

Esomeprazole is a proton pump inhibitor that reduces stomach acid by blocking the H+/K+ ATPase pump in gastric parietal cells. Domperidone is a dopamine (D2) receptor antagonist that increases gastric motility and helps relieve nausea and reflux by improving stomach emptying.

How to take Neksium D 40/30 mg Capsule

Capsule (SR): take exactly as prescribed, usually once daily 30 minutes before food (preferably before breakfast). Swallow whole; do not crush, chew or open the capsule. If a dose is missed, take it when remembered unless it is near the next dose.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause drowsiness, disorientation and abnormal muscle movements. It may cause confusion, blurred vision, sweating and a fast heartbeat. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Neksium D 40/30 mg Capsule

Most side effects of Neksium D 40/30 mg are mild and settle as the body adjusts. Reported side effects include:

• Headache
• diarrhea
• abdominal pain
• nausea
• flatulence
• dry mouth
• dizziness
• constipation

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Neksium D 40/30 mg Capsule

Warnings and precautions

Do not use if allergic to esomeprazole/domperidone or other PPIs. Domperidone may increase risk of QT prolongation/serious heart rhythm problems—use caution in heart disease, electrolyte imbalance, and in older patients; avoid with known prolonged QT. Prolonged PPI use may be associated with low magnesium, vitamin B12 deficiency, fractures, and C. difficile-associated diarrhea; seek care for severe/persistent diarrhea. May mask symptoms of gastric cancer—consult doctor for alarm symptoms (weight loss, vomiting blood, black stools, difficulty swallowing). Use caution in severe liver disease; kidney disease: consult doctor.

Do not take Neksium D 40/30 mg if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with bleeding, blockage or perforation of the gut, or with certain heart rhythm disorders.

Interactions with other medicines

QT-prolonging drugs (e.g., amiodarone, sotalol, certain antipsychotics/antidepressants), strong CYP3A4 inhibitors (e.g., ketoconazole/itraconazole, erythromycin/clarithromycin, ritonavir) increase domperidone levels and arrhythmia risk; warfarin (monitor INR), clopidogrel (reduced activation possible with some PPIs), digoxin, methotrexate (high dose), atazanavir/nelfinavir (reduced absorption with PPIs), iron salts and other drugs needing acidic pH (reduced absorption)

How to store Neksium D 40/30 mg Capsule

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Expert advice for Neksium D 40/30 mg Capsule

Take it shortly before meals for bloating and early fullness. Sip fluids frequently in small amounts, and use oral rehydration salts if you have been vomiting. Take it before breakfast, not after a meal. Eat smaller meals, avoid late dinners, raise the head of your bed and avoid smoking — these do as much as the tablet for reflux.

Manufacturer and class

Manufacturer:

CIPLA LIMITED

Therapeutic class:

Anti-reflux/Anti-ulcerant (PPI + Prokinetic)

Drug class:

Proton pump inhibitor (esomeprazole) + dopamine D2 antagonist prokinetic/antiemetic (domperidone)