
Bisonew 1.25MG Tab
Verse Lifesciences - Tablet - 1.25 mg - 10 S
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Glimepiride 2 mg + Metformin (extended-release) 1000 mg + Dapagliflozin 10 mg
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Humiglim M2 Forte Dapa Tablet is used for type 2 diabetes mellitus to improve blood sugar control in adults, especially when diet and exercise alone are insufficient.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Humiglim M2 Forte Dapa Tablet contains Glimepiride 2 mg + Metformin (extended-release) 1000 mg + Dapagliflozin 10 mg. It belongs to the Sulfonylurea + Biguanide + SGLT2 inhibitor class of medicines.
Glimepiride (sulfonylurea) increases insulin release from the pancreas. Metformin ER reduces glucose production in the liver and improves insulin sensitivity. Dapagliflozin (SGLT2 inhibitor) lowers blood sugar by increasing urinary glucose excretion.
Oral tablet. Take exactly as prescribed, usually once daily with food (preferably with the main meal) to reduce stomach upset. Swallow whole; do not crush/chew (ER component). Monitor blood glucose regularly.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It can cause dehydration and a fall in blood pressure. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Humiglim M2 Forte Dapa are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended; consult doctor (insulin is usually preferred in pregnancy) |
|---|---|
| Breastfeeding | Not recommended while breastfeeding. |
| Alcohol | Avoid |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Risk of hypoglycaemia (higher with missed meals, alcohol, strenuous exercise or with other antidiabetics); metformin may rarely cause lactic acidosis (risk increased in kidney/liver impairment, dehydration, heavy alcohol intake, severe infection, hypoxia)—seek urgent care for severe weakness, breathing trouble, abdominal pain. Dapagliflozin can cause dehydration/low BP, genital mycotic infections, UTIs, and rare ketoacidosis even with near-normal sugars—stop and seek care if nausea/vomiting, abdominal pain, rapid breathing occur. Avoid/use with caution in renal impairment; assess eGFR before and during therapy. Hold metformin around iodinated contrast/surgery as advised by doctor. Not for type 1 diabetes.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for people with severe kidney disease.
Insulin/other sulfonylureas (additive hypoglycaemia), alcohol (increases hypoglycaemia and lactic acidosis risk), diuretics (dehydration/hypotension), ACE inhibitors/ARBs (may enhance glucose-lowering), corticosteroids and thiazides (raise glucose), rifampicin/phenytoin (reduce sulfonylurea effect), azole antifungals/clarithromycin (may increase sulfonylurea effect), cimetidine and other renal tubular secretion inhibitors (may increase metformin levels), iodinated contrast media (lactic acidosis risk)
Store below 25°C in a dry place, protected from moisture and light. Keep in original strip and out of reach of children.
Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them. Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine.

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The information on Humiglim M2 Forte Dapa Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.