K-Pio 15 mg

Composition of K-Pio 15 mg

K-Pio 15 mg contains Pioglitazone 15 mg (as pioglitazone hydrochloride). It belongs to the Thiazolidinedione (PPAR-gamma agonist) class of medicines.

Uses of K-Pio 15 mg

• Type 2 diabetes mellitus to improve blood sugar control
• as monotherapy or in combination with other antidiabetic medicines (e.g.
• metformin
• sulfonylureas
• insulin) along with diet and exercise

Key benefits

• Improves insulin sensitivity
• Helps lower fasting and post-meal blood glucose
• Supports HbA1c reduction
• Can be used alone or with other antidiabetic medicines
• Helps control blood sugar with diet and exercise

How K-Pio 15 mg works

Pioglitazone is a thiazolidinedione that activates PPAR-γ receptors, increasing insulin sensitivity in adipose tissue, muscle and liver. It reduces insulin resistance, decreases hepatic glucose production and improves peripheral glucose uptake.

How to take K-Pio 15 mg

Oral tablet. Take exactly as prescribed, usually once daily at the same time each day, with or without food. Continue diet and exercise; monitor blood glucose regularly. Do not stop or change dose without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine may cause low blood sugar and marked stomach upset. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of K-Pio 15 mg

Most side effects of K-Pio are mild and settle as the body adjusts. Reported side effects include:

• Weight gain
• edema (swelling)
• headache
• dizziness
• upper respiratory tract infection
• muscle pain
• diarrhea
• increased appetite

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for K-Pio 15 mg

Warnings and precautions

Not for type 1 diabetes or diabetic ketoacidosis. Can cause or worsen heart failure—contraindicated in NYHA class III/IV; seek help for rapid weight gain, swelling or shortness of breath. Risk of fluid retention especially with insulin. Monitor liver function; avoid if active liver disease or significant ALT elevation. May increase risk of bone fractures (especially in women). Rare risk of macular edema—report vision changes. Use with caution in patients with history of bladder cancer or unexplained hematuria; assess risk/benefit. May cause ovulation in anovulatory women—use contraception if needed.

Do not take K-Pio if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with heart failure, active bladder cancer or unexplained blood in the urine.

Interactions with other medicines

Insulin or other antidiabetics (increased risk of hypoglycemia/edema), gemfibrozil (increases pioglitazone levels), rifampicin (reduces pioglitazone levels), oral contraceptives (may reduce hormone levels), corticosteroids/NSAIDs (may increase fluid retention)

How to store K-Pio 15 mg

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Expert advice for K-Pio 15 mg

Take it with the first mouthful of your meal so it can act on that meal. Expect some wind in the first weeks; it usually settles.

Manufacturer and class

Manufacturer:

BLUE CROSS LABORATORIES LTD`

Therapeutic class:

Antidiabetic

Drug class:

Thiazolidinedione (PPAR-gamma agonist)