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Prescription requiredIpca Laboratories Ltd`PAIN ANALGESICS

Lefno 20 mg Tablet

Leflunomide (20mg)

Lefno 20 mg Tablet is used for treatment of Rheumatoid arthritis.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated August 2026

₹303₹30.28 per tablet
100% genuine medicinesPharmacist-verified orderDelivered across India

Key details

Salt: Leflunomide (20mg)
Available variants: tablet 20 mg 10`S
Best price: ₹303 (₹30.28 per tablet)
Prescription: Required
Manufacturer: IPCA LABORATORIES LTD`

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Same salt, lower price

Medicines with the same active ingredient and strength as Lefno 20 mg Tablet.

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Lefno 20 mg Tablet

tablet - 20 mg - 10 S

₹303

₹30.28 per tablet

  • Lefra 10 Tab 10S

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  • Lefutoid 20MG Tab

    LUPIN LAB · tablet - 20 mg - 10 S · Rx

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Compare all substitutes
Same salt, different brand — what does that mean?

A substitute contains the same active ingredient (salt), in the same strength, as Lefno 20 mg Tablet. The medicine inside is the same — the brand name, manufacturer and price are what differ.

All medicines sold in India, branded or generic, must meet the quality standards set by the national drug regulator (CDSCO). A lower price does not mean lower quality.

Please confirm with your doctor or pharmacist before switching brands — they will check that the strength and form match your prescription.

Composition of Lefno 20 mg Tablet

Lefno 20 mg Tablet contains Leflunomide (20mg).

Uses of Lefno 20 mg Tablet

Treatment of Rheumatoid arthritis

Key benefits

  • In Treatment of Rheumatoid arthritis Lefno 20 Tablet reduces pain
  • stiffness
  • and swelling in your joints and slows down the progression of bone and joint damage. This will help you do normal daily activities more easily and thus improve your quality of life. This medicine should be taken at the same time each day to get maximum benefits. Keep taking it even if you feel well because it is preventing future harm as well as improving your symptoms.

How Lefno 20 mg Tablet works

Lefno 20 Tablet blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain autoimmune diseases such as rheumatoid arthritis. It suppresses the underlying disease process, rather than simply treating the disease.

How to take Lefno 20 mg Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lefno 20 Tablet may be taken with or without food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Lefno 20 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

Taking more Lefno than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Lefno 20 mg Tablet

Most side effects of Lefno are mild and settle as the body adjusts. Reported side effects include:

  • Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Lefno 20 mg Tablet

PregnancyPregnancy UNSAFE
BreastfeedingBreast feeding UNSAFE
AlcoholAlcohol UNSAFE
DrivingDriving CONSULT YOUR DOCTOR
KidneyKidney UNSAFE
LiverLiver UNSAFE
Habit formingNo

Interactions with other medicines

Tell your doctor or pharmacist about every medicine you take, including over-the-counter products, vitamins and herbal or ayurvedic preparations, before starting Lefno. Some combinations can change how Lefno works or raise the chance of side effects.

How to store Lefno 20 mg Tablet

Store Lefno below 30°C in a cool, dry place away from direct sunlight and moisture. Keep the pack tightly closed and out of the reach of children. Do not use it after the expiry date printed on the pack.

Expert advice for Lefno 20 mg Tablet

You have been prescribed Lefno 20 Tablet to control the symptoms and slow down the progression of rheumatoid arthritis. It will take 6-8 weeks for Lefno 20 Tablet to work. Hence, keep taking the medicine. Get blood tests done every 4 weeks. This is to make sure that Lefno 20 Tablet is not harming your liver or blood counts. Avoid alcohol when taking Lefno 20 Tablet as it could harm your liver. Do not take it during pregnancy or breastfeeding. Tell your doctor if you become pregnant while taking Lefno 20 Tablet. Lefno 20 Tablet may increase the risk of infection. Avoid being close to people with colds, flu, or other contagious illnesses.

Manufacturer and class

Manufacturer:
IPCA LABORATORIES LTD`
Therapeutic class:
PAIN ANALGESICS
Chemical class:
Aromatic anilides

Substitutes for Lefno 20 mg Tablet

Medicines with the same active ingredient (Leflunomide (20mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Lefno 20 mg Tablet
Lefra 10 TabletTorrent Pharmaceuticals Ltdtablet · 10`S₹15549% cheaper
Lefutoid 20 mg TabletLUPIN LABtablet · 10`S₹2759% cheaper
Lefra 20 TabletTorrent Pharmaceuticals Ltdtablet · 10`S₹302same price
See all substitutes and alternatives

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Lefno 20 mg Tablet FAQs

What is Lefno 20 mg Tablet used for?
Lefno 20 mg Tablet is commonly used for Treatment of Rheumatoid arthritis. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Lefno 20 mg Tablet?
Lefno 20 mg Tablet contains Leflunomide (20mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Lefno 20 mg Tablet?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Lefno 20 mg Tablet work?
Lefno 20 Tablet blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain autoimmune diseases such as rheumatoid arthritis.
Is Lefno 20 mg Tablet a prescription medicine?
Yes. Lefno 20 mg Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Lefno 20 mg Tablet?
The side effects reported most often with Lefno are Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Lefno 20 mg Tablet be taken during pregnancy?
Pregnancy UNSAFE Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Lefno.
Can I drink alcohol while taking Lefno 20 mg Tablet?
Alcohol UNSAFE
What if I miss a dose of Lefno 20 mg Tablet?
If you miss a dose of Lefno 20 Tablet, take it as soon as possible.
Is Lefno 20 mg Tablet habit forming?
No. Lefno 20 mg Tablet is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Lefno 20 mg Tablet?
Lefra 10 Tablet has the same active ingredient and strength and is listed from ₹155 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Lefno 20 mg Tablet cost on PingMeDoc Pharmacy?
Lefno 20 mg Tablet starts at ₹303 on PingMeDoc Pharmacy. Available in tablet 20 mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Lefno 20 mg Tablet?
Lefno 20 mg Tablet is manufactured by IPCA LABORATORIES LTD`. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Lefno 20 mg Tablet delivered?
Lefno 20 mg Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Lefno 20 mg Tablet, Quick facts

Salt
Leflunomide (20mg)
Form
tablet
Best price
₹303 (₹30.28 per tablet)
Prescription
Required (Rx)
Schedule
Schedule H
Brand
IPCA LABORATORIES LTD`
Manufacturer
IPCA LABORATORIES LTD`
Therapeutic class
PAIN ANALGESICS
Chemical class
Aromatic anilides
Action class
Non-Biologic DMARDs (Disease Modifying Anti-Rheumatoid Drugs)
Habit forming
No
Variants
tablet 20 mg 10`S
Delivery
Standard across India

References

The information on Lefno 20 mg Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  2. National List of Essential Medicines (NLEM) 2022, Government of India.
  3. Manufacturer's package insert / prescribing information for Lefno 20 mg Tablet.
  4. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

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Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.