
Acuclav 375
Macleods Pharmaceuticals Pvt Ltd - 10 S
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Isoniazid (50mg) + Pyrazinamide (300mg) + Rifampicin (100mg)
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Macox Zh Kid is used for tuberculosis (TB).
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Macox Zh Kid contains Isoniazid (50mg) + Pyrazinamide (300mg) + Rifampicin (100mg). It belongs to the Anti-tuberculosis agent class of medicines.
Tuberculosis (TB)
Macox-ZH Kid Tablet DT is a combination of three medicines: Isoniazid, Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide, on the other hand works by slowing the growth of these bacteria.
Take exactly as prescribed by your doctor.
Most side effects of Macox Zh Kid are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding SAFE IF PRESCRIBED |
| Alcohol | Alcohol UNSAFE |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver CAUTION |
| Habit forming | No |
TB treatment must be taken every day for the whole course, usually six months or more. Stopping early is the main cause of drug-resistant TB, which is far harder to treat. Rifampicin turns urine, sweat and tears orange-red. This is harmless, but it permanently stains soft contact lenses. Report yellowing of the eyes or skin, dark urine, persistent vomiting or severe tiredness at once — the liver needs checking. Report any change in vision, including colour vision, immediately if you are on ethambutol. Rifampicin makes hormonal contraception unreliable. Use an additional method throughout and for a period after the course.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Your doctor will adjust or change the regimen in significant liver disease.
Rifampicin reduces the effect of a very large number of medicines, including contraceptives, blood thinners, steroids, some heart and HIV medicines. Vitamin B6 is usually given alongside isoniazid to prevent nerve damage — take it as prescribed.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Macox-ZH Kid Tablet DT should be taken on an empty stomach but at the same time every day. Do not skip any doses and finish the full course of treatment even if you feel better. It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Macox-ZH Kid Tablet DT affects you. Avoid drinking alcohol while taking this medicine as this may increase the risk of side effects on the liver. Avoid taking hormone-based birth control methods as Macox-ZH Kid Tablet DT may decrease their effectiveness. Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.

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The information on Macox Zh Kid is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.