Macrozide 750

Composition of Macrozide 750

Macrozide 750 contains Pyrazinamide (750mg). It belongs to the Anti-tuberculosis agent class of medicines.

Uses of Macrozide 750

Tuberculosis (TB)

Key benefits

• In Tuberculosis (TB) Macrozide 750 Tablet is used to treat tuberculosis
• an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

How Macrozide 750 works

Macrozide 750 Tablet is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.

How to take Macrozide 750

Take exactly as prescribed by your doctor.

Side effects of Macrozide 750

Most side effects of Macrozide are mild and settle as the body adjusts. Reported side effects include:

• Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Macrozide 750

Warnings and precautions

TB treatment must be taken every day for the whole course, usually six months or more. Stopping early is the main cause of drug-resistant TB, which is far harder to treat. Rifampicin turns urine, sweat and tears orange-red. This is harmless, but it permanently stains soft contact lenses. Report yellowing of the eyes or skin, dark urine, persistent vomiting or severe tiredness at once — the liver needs checking. Report any change in vision, including colour vision, immediately if you are on ethambutol. Rifampicin makes hormonal contraception unreliable. Use an additional method throughout and for a period after the course.

Do not take Macrozide if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Your doctor will adjust or change the regimen in significant liver disease.

Interactions with other medicines

Rifampicin reduces the effect of a very large number of medicines, including contraceptives, blood thinners, steroids, some heart and HIV medicines. Vitamin B6 is usually given alongside isoniazid to prevent nerve damage — take it as prescribed.

How to store Macrozide 750

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Macrozide 750

Macrozide 750 Tablet along with other medications effectively treats tuberculosis. Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects. Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Avoid drinking alcohol while taking Macrozide 750 Tablet as this may increase the risk of side effects on the liver. Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Macrozide 750 Tablet as it may make hormonal contraceptives such as the pill less effective.

Manufacturer and class

Manufacturer:

MACLEODS PHARMACEUTICALS LTD

Therapeutic class:

ANTI INFECTIVES

Drug class:

Anti-tuberculosis agent

Chemical class:

Pyrazines