Nexvenla OD Plus Tablet

Composition of Nexvenla OD Plus Tablet

Nexvenla OD Plus Tablet contains Desvenlafaxine (50mg) + Clonazepam (0.5mg). It belongs to the Antidepressant and Benzodiazepine / sedative-hypnotic class of medicines.

Uses of Nexvenla OD Plus Tablet

Treatment of Depression

Key benefits

• In Treatment of Depression Nexvenla OD Plus Tablet helps in maintaining the balance of certain chemicals in the brain that affect mood and behavior. This improves your mood
• relieves anxiety
• tension
• helps you sleep better and increases your energy levels. Nexvenla OD Plus Tablet prevents extreme changes in mood and helps you feel less agitated. You may experience fewer episodes of depression and low mood. It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor tells you to.

How Nexvenla OD Plus Tablet works

Nexvenla OD Plus Tablet is a combination of two medicines: Desvenlafaxine and Clonazepam. Desvenlafaxine is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Clonazepam is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach, which helps in the relief of acid-related indigestion and heartburn.

How to take Nexvenla OD Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nexvenla OD Plus Tablet may be taken with or without food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Nexvenla OD Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. It can cause deep unconsciousness and dangerously slow breathing, particularly with alcohol or an opioid. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Nexvenla OD Plus Tablet

Most side effects of Nexvenla OD Plus are mild and settle as the body adjusts. Reported side effects include:

• Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Nexvenla OD Plus Tablet

Warnings and precautions

These medicines take two to four weeks to begin working, and longer for the full effect. Stopping at two weeks because nothing has changed is the commonest mistake. Never stop suddenly. Abrupt withdrawal causes dizziness, electric-shock sensations, irritability and flu-like symptoms — your doctor will reduce the dose gradually. Tell your doctor or go to hospital immediately if thoughts of harming yourself appear or worsen, particularly in the first weeks or after a dose change, and especially in anyone under twenty-five. Seek urgent care for agitation with fever, shivering, a racing heart, muscle twitching or confusion, particularly if more than one medicine affecting serotonin is being taken. Side effects are usually worst in the first fortnight and then settle. These medicines cause dependence. They are intended for the shortest possible course — usually two to four weeks — and are not a long-term treatment for anxiety or sleeplessness. Never stop a regular course suddenly. Withdrawal can cause severe anxiety, tremor and fits. Your doctor will taper it slowly. Do not drive or operate machinery. Drowsiness and slowed reactions can continue into the next day. Never combine with alcohol or with opioid painkillers — together they can stop your breathing. Older people are far more likely to fall, become confused or have memory problems on these medicines. Several of these are Schedule H1 medicines and must be dispensed against a prescription and entered in the pharmacy register.

Do not take Nexvenla OD Plus if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one. Not for people with severe breathing problems, sleep apnoea, or severe liver disease. Not for anyone with a history of dependence, except under specialist supervision.

Interactions with other medicines

Tramadol, triptans for migraine, linezolid, St John's wort and other antidepressants can together raise serotonin dangerously. Anti-inflammatory painkillers and blood thinners increase the bleeding risk when combined with this group. Alcohol, opioids, antihistamines, muscle relaxants and other sedatives all deepen the sedation, sometimes fatally.

How to store Nexvenla OD Plus Tablet

Store at room temperature (below 25°C), protected from moisture and light. Keep out of reach of children.

Expert advice for Nexvenla OD Plus Tablet

You have been prescribed Nexvenla OD Plus Tablet for the treatment of depression. Inform your doctor immediately if you get thoughts about harming yourself or ending your life. It is also advisable to inform your doctor if you get aggressive, anxiety, trouble sleeping, an increase in activity or talking more than what is normal for you, and other unusual changes in behavior or mood. Do not stop taking Nexvenla OD Plus Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary. Inform your doctor if you are taking any other antidepressants. If you have hypertension, monitor your blood pressure regularly while taking Nexvenla OD Plus Tablet. Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

Manufacturer and class

Manufacturer:

ALKEM LAB

Therapeutic class:

NEURO CNS

Drug class:

Antidepressant and Benzodiazepine / sedative-hypnotic