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Prescription requiredIcon PharmaNeuropathic pain agent and Antidepressant
Predulox Ls Capsule
Pregabalin (50mg) + Duloxetine (10mg)
Available at our pharmacy counter
This medicine is dispensed in person against a valid prescription and is not sold online. Ask our pharmacist about availability, or speak to a registered doctor.
In-store reference price ₹123
Predulox Ls Capsule is used for this medicine is used in the treatment of nerve pain, diabetic neuropathy, pain after shingles, fibromyalgia, epilepsy, depression, anxiety, obsessive compulsive disorder and migraine prevention.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated October 2026
Licensed pharmacyPharmacist-verified order
Key details
Salt: Pregabalin (50mg) + Duloxetine (10mg)
Available variants: capsule 50mg + 10mg 10`S
Best price: ₹123 (₹12.26 per capsule)
MRP: ₹129
Prescription: Required
Manufacturer: ICON PHARMA
Ordering notes
This medicine is dispensed in person at a licensed pharmacy counter and is not delivered.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy
Composition of Predulox Ls Capsule
Predulox Ls Capsule contains Pregabalin (50mg) + Duloxetine (10mg). It belongs to the Gabapentinoid and Antidepressant class of medicines.
Uses of Predulox Ls Capsule
- Nerve pain
- Diabetic neuropathy
- Pain after shingles
- Fibromyalgia
- Epilepsy
- Depression
- Anxiety
- Obsessive compulsive disorder
- Migraine prevention
Benefits of Predulox Ls Capsule
- In Nerve pain
- Predulox Ls calms over-active nerves so the burning, shooting and electric-shock pains of nerve damage ease. Relief builds over one to two weeks.
- In Diabetic neuropathy
- Predulox Ls eases the burning, tingling and numbness in the feet and hands caused by diabetic nerve damage, improving sleep and comfort.
- In Pain after shingles
- Predulox Ls relieves the persistent, sensitive pain that can linger in the skin after a shingles rash has healed.
- In Fibromyalgia
- Predulox Ls reduces the widespread pain and improves the sleep disturbance of fibromyalgia.
- In Epilepsy
- Predulox Ls steadies the electrical activity in the brain, reducing how often seizures occur when taken alongside other anti-epileptic medicines.
- In Depression
- Predulox Ls restores the balance of the brain's chemical messengers, gradually lifting mood, energy, sleep and appetite. The benefit builds over several weeks, which is why it is important to keep taking it.
- In Anxiety
- Predulox Ls calms persistent worry and the physical tension that goes with it, so that everyday situations feel manageable again.
- In Obsessive compulsive disorder
- Predulox Ls reduces the intrusive thoughts and the urge to repeat rituals, usually alongside talking therapy.
- In Migraine prevention
- Predulox Ls, taken every day, reduces how often migraines come and how severe they are. It does not treat an attack once it has started.
How Predulox Ls Capsule works
This medicine combines 2 active ingredients: Pregabalin and Duloxetine. Pregabalin calms the over-active nerve signals that cause burning, shooting and tingling pain. Duloxetine restores the balance of the chemical messengers in the brain that regulate mood, sleep and the way pain is felt.
How to take Predulox Ls Capsule
Swallow the capsule whole with a glass of water. Do not chew, crush or break it unless your doctor has told you to. Take it with or without food. Taking it at about the same time each day helps you remember. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Missed dose and overdose
If you miss a dose
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
If you take too much
An overdose of this medicine can cause deep drowsiness, confusion, unsteadiness and slowed breathing, especially with an opioid or alcohol. It can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Side effects of Predulox Ls Capsule
Most side effects of Predulox Ls are mild and settle as the body gets used to the medicine. The ones reported most often are:
- Drowsiness
- Dizziness
- Swelling of the ankles and feet
- Weight gain
- Blurred vision
- Unsteadiness
- Nausea
- Dry mouth
- Drowsiness or difficulty sleeping
- Headache
- Weight change
- Reduced sexual desire
- Constipation
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Safety advice for Predulox Ls Capsule
- AlcoholUNSAFE
- Do not drink alcohol while taking this medicine.
- PregnancyUNSAFE
- Not recommended in pregnancy. It may harm the developing baby, so tell your doctor at once if you are or might be pregnant.
- Breast feedingCONSULT YOUR DOCTOR
- Consult your doctor before using this while breastfeeding.
- DrivingUNSAFE
- Do not drive or operate machinery while taking this medicine.
- KidneyCONSULT YOUR DOCTOR
- Consult your doctor if you have kidney disease.
- LiverCONSULT YOUR DOCTOR
- Consult your doctor if you have liver disease.
- Habit formingYES
- This medicine can cause dependence with prolonged use. Take it only under medical supervision and do not stop it abruptly.
Warnings and precautions
This medicine causes drowsiness and unsteadiness, particularly when you start it or the dose goes up. Do not drive or operate machinery until you know how it affects you. Never stop it suddenly. Stopping abruptly can cause anxiety, sleeplessness, sweating and, in people taking it for epilepsy, fits. Your doctor will taper it. Tell your doctor about any change in mood or any thoughts of harming yourself. The dose is usually built up slowly from a low starting point — follow the schedule your doctor gave you rather than jumping to the full dose. Pregabalin comes under Schedule H1 from 16 November 2026 and will then need a prescription and a pharmacy register entry. These medicines take two to four weeks to begin working, and longer for the full effect. Stopping at two weeks because nothing has changed is the commonest mistake. Never stop suddenly. Abrupt withdrawal causes dizziness, electric-shock sensations, irritability and flu-like symptoms — your doctor will reduce the dose gradually. Tell your doctor or go to hospital immediately if thoughts of harming yourself appear or worsen, particularly in the first weeks or after a dose change, and especially in anyone under twenty-five. Seek urgent care for agitation with fever, shivering, a racing heart, muscle twitching or confusion, particularly if more than one medicine affecting serotonin is being taken. Side effects are usually worst in the first fortnight and then settle.
Do not take Predulox Ls if
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one.
Interactions with other medicines
Opioid painkillers, alcohol, sleeping tablets and antihistamines all add to the drowsiness, and the combination with opioids can dangerously slow breathing. Antacids reduce the absorption of gabapentin — separate them by a couple of hours. Tramadol, triptans for migraine, linezolid, St John's wort and other antidepressants can together raise serotonin dangerously. Anti-inflammatory painkillers and blood thinners increase the bleeding risk when combined with this group.
How to store Predulox Ls Capsule
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Quick tips for Predulox Ls Capsule
- Take the larger part of the dose at night if drowsiness is a problem.
- Rise slowly from sitting or lying, especially in the first weeks.
- Keep your review appointment so the dose can be adjusted to the lowest that controls your pain.
- Give it a fair trial of several weeks, and keep your review appointments.
- Take it at the same time each day.
- At night if it makes you drowsy, in the morning if it disturbs sleep.
- Talking therapy alongside medicine works better than either alone for most people.
Manufacturer and class
- Manufacturer:
- ICON PHARMA
- Therapeutic class:
- Neuropathic pain agent and Antidepressant
- Drug class:
- Gabapentinoid and Antidepressant
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Predulox Ls Capsule FAQs
What is Predulox Ls Capsule used for?
Predulox Ls Capsule is commonly used for nerve pain, diabetic neuropathy, pain after shingles, fibromyalgia, epilepsy, depression, anxiety, obsessive compulsive disorder and migraine prevention. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What are the benefits of Predulox Ls Capsule?
Nerve pain: Predulox Ls calms over-active nerves so the burning, shooting and electric-shock pains of nerve damage ease. Relief builds over one to two weeks. It is also used for diabetic neuropathy, pain after shingles, fibromyalgia.
What is the salt in Predulox Ls Capsule?
Predulox Ls Capsule contains Pregabalin (50mg) + Duloxetine (10mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Predulox Ls Capsule?
Swallow the capsule whole with a glass of water. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Predulox Ls Capsule work?
This medicine combines 2 active ingredients: Pregabalin and Duloxetine.
Is Predulox Ls Capsule a prescription medicine?
Yes. Predulox Ls Capsule is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Predulox Ls Capsule?
The side effects reported most often with Predulox Ls are Drowsiness, Dizziness, Swelling of the ankles and feet, Weight gain, Blurred vision. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Predulox Ls Capsule be taken during pregnancy?
Predulox Ls Capsule is not recommended in pregnancy. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Predulox Ls.
Can I drink alcohol while taking Predulox Ls Capsule?
No. Do not drink alcohol while taking Predulox Ls Capsule.
What if I miss a dose of Predulox Ls Capsule?
Take it as soon as you remember.
Is Predulox Ls Capsule habit forming?
Yes. Predulox Ls Capsule can cause dependence with prolonged use. Take Predulox Ls only as directed and for the duration your doctor advises.
How much does Predulox Ls Capsule cost on PingMeDoc Pharmacy?
Predulox Ls Capsule starts at ₹123 (MRP ₹129) on PingMeDoc Pharmacy. Available in capsule 50mg + 10mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Predulox Ls Capsule?
Predulox Ls Capsule is manufactured by ICON PHARMA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Predulox Ls Capsule delivered?
Predulox Ls Capsule is a regulated medicine and is not delivered. It is dispensed in person at a licensed pharmacy counter against a valid prescription. Ask our pharmacist on WhatsApp about availability.
Predulox Ls Capsule, Quick facts
- Salt
- Pregabalin (50mg) + Duloxetine (10mg)
- Form
- capsule
- Best price
- ₹123 (₹12.26 per capsule)
- MRP
- ₹129
- Prescription
- Required (Rx)
- Schedule
- Schedule H
- Brand
- ICON PHARMA
- Manufacturer
- ICON PHARMA
- Therapeutic class
- Neuropathic pain agent and Antidepressant
- Drug class
- Gabapentinoid and Antidepressant
- Habit forming
- Yes
- Variants
- capsule 50mg + 10mg 10`S
- Delivery
- Standard across India
References
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.
- PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
- CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
- Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
- National List of Essential Medicines (NLEM) 2022, Government of India.
- Manufacturer's package insert / prescribing information for Predulox Ls Capsule.
- World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.
Next steps
Safety disclaimer
Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.