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Dextromethorphan (5mg/5ml) + Chlorpheniramine (1mg/5ml)
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Protussa is used for protussa Cough Syrup is used in the treatment of dry cough. It is used for the temporary relief of cough due to throat irritation, sneezing, and running nose.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Protussa contains Dextromethorphan (5mg/5ml) + Chlorpheniramine (1mg/5ml). It belongs to the Expectorant / mucolytic / bronchodilator and Antihistamine / leukotriene antagonist class of medicines.
Protussa Cough Syrup is a combination of two medicines: Chlorpheniramine Maleate and Dextromethorphan Hydrobromide, which relieves dry cough. Chlorpheniramine Maleate is an antiallergic which helps reduce cough associated with allergies by blocking the effects of a chemical messenger, histamine. Dextromethorphan Hydrobromide is a cough suppressant which relieves cough by reducing the activity of cough center in the brain.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Protussa Cough Syrup may be taken with or without food, but it is better to take it at a fixed time.<br>Take it with food if stomach upset occurs.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause vomiting, severe drowsiness, a racing heart and, with codeine, dangerously slow breathing. It can cause severe drowsiness, a fast heartbeat, confusion and, in children, agitation and fits. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Protussa are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Protussa Cough Syrup may be unsafe to use during pregnancy.<br>Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor. |
|---|---|
| Breastfeeding | Protussa Cough Syrup is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby. |
| Alcohol | Protussa Cough Syrup may cause excessive drowsiness and calmness with alcohol. |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Protussa Cough Syrup is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Protussa Cough Syrup may not be needed in these patients. Please consult your doctor. |
| Liver | Protussa Cough Syrup is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor. |
| Habit forming | No |
See a doctor if a cough lasts more than a week, or comes with fever, breathlessness, chest pain or blood in the sputum. Do not give cough and cold preparations to young children except on a doctor's advice. Do not combine two cough preparations — they frequently contain the same ingredients, and the doses add up. Preparations containing codeine can cause dependence and must be used only for the period your doctor specifies. Older antihistamines cause marked drowsiness — do not drive or operate machinery until you know how this affects you. Tell your doctor promptly about any change in mood, sleep, agitation or unusual thoughts while taking montelukast; this is uncommon but recognised. This relieves the symptoms of an allergy; it does not treat the cause, and it is not a treatment for an acute asthma attack. Seek emergency care for swelling of the lips, tongue or throat, or difficulty breathing.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Codeine-containing preparations are not for children, or for anyone with breathing difficulty. The sedating antihistamines are not suitable for very young children, or for people with glaucoma or an enlarged prostate, without medical advice.
Sedating ingredients add to the effect of alcohol and sleeping tablets. Decongestants such as phenylephrine and pseudoephedrine can raise blood pressure — tell your doctor if you are hypertensive. Alcohol, sleeping tablets and other sedating medicines add to the drowsiness. Tell your doctor about all cold and cough preparations — many already contain an antihistamine.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Drink plenty of water — it thins mucus better than any syrup. Steam inhalation helps congestion and costs nothing. Measure the dose with the cup supplied. Taking it at bedtime reduces the impact of any drowsiness. Identify and avoid your triggers where you can — dust, pollen, cold air.
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The information on Protussa is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.