
Actibile 150MG Tab
Zydus Healthcare Pharma - Tablet - 150 mg - 10 S
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Fluconazole (150mg) + Azithromycin (1000mg) + Secnidazole (1000mg)
Safkit Tablet is used for syndromic treatment of vaginal discharge.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Safkit Tablet contains Fluconazole (150mg) + Azithromycin (1000mg) + Secnidazole (1000mg). It belongs to the Systemic antifungal, Macrolide and Antibacterial agent class of medicines.
Syndromic treatment of vaginal discharge
Safkit 150 mg/1000 mg/1000 mg Tablet is a combination of fluconazole, azithromycin, and secnidazole. It works by targeting different types of microorganisms responsible for vaginal infections. Fluconazole acts against fungal pathogens by disrupting their cell membrane, Azithromycin inhibits bacterial growth by interfering with protein synthesis, and Secnidazole is active against anaerobic bacteria and protozoa by damaging their DNA. Together, they help control mixed infections associated with vaginal discharge and support effective resolution of symptoms.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Safkit 150 mg/1000 mg/1000 mg Tablet should be taken with or after food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Safkit 150 mg/1000 mg/1000 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause vomiting, liver injury and heart rhythm disturbance. It can cause vomiting, hearing disturbance and heart rhythm changes. It can cause vomiting, severe loose motions and nerve symptoms. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Safkit are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy UNSAFE |
|---|---|
| Breastfeeding | Breast feeding UNSAFE |
| Alcohol | Alcohol UNSAFE |
| Driving | Driving CONSULT YOUR DOCTOR |
| Kidney | Kidney CAUTION |
| Liver | Liver UNSAFE |
| Habit forming | No |
Fungal skin and nail infections need long courses — weeks for skin, months for nails. Stopping when it looks better is the commonest reason it returns. Your doctor may check your liver with a blood test during a long course. Report yellowing of the eyes or skin, dark urine or persistent nausea at once. Tell your doctor if you have heart failure before taking itraconazole. This group interacts with a great many medicines — give your doctor a complete list. Finish the whole course even after you feel better. Tell your doctor if you have a heart rhythm problem or take a medicine for one — this group can affect the heart's electrical timing. Report severe or watery loose motions during or after the course rather than treating them yourself. Do not drink any alcohol while taking metronidazole, ornidazole or tinidazole, or for the period after the course that your doctor states — the combination causes severe flushing, vomiting and a racing heart. Tetracyclines stain developing teeth and are avoided in young children and in pregnancy. Antibiotics do not work against colds, flu or most sore throats, which are caused by viruses.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with active liver disease, and several are not for use in pregnancy. Itraconazole is not for people with heart failure. Not for anyone with a known allergy to macrolide antibiotics, or with certain heart rhythm disorders.
Interacts strongly with statins, some heart medicines, blood thinners and sedatives — some combinations must be avoided altogether. Acid-reducing medicines lower the absorption of itraconazole. Interacts with a long list of medicines, including statins, some heart medicines and blood thinners — tell your doctor everything you take. Antacids reduce absorption; separate them by a couple of hours. Antacids, iron, zinc and calcium reduce the absorption of tetracyclines — separate them by a couple of hours. Tell your doctor if you take a blood thinner.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Safkit 150 mg/1000 mg/1000 mg Tablet should be taken with food at the same time every day. Do not skip any doses and finish the full course of treatment even if you feel better. It is advisable to stay hydrated and drink plenty of water to overcome medicine side effects. It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Safkit 150 mg/1000 mg/1000 mg Tablet affects you. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

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The information on Safkit Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.