Sitaglyn M Ir 50/1000 Tablet

Composition of Sitaglyn M Ir 50/1000 Tablet

Sitaglyn M Ir 50/1000 Tablet contains Metformin (1000mg) + Sitagliptin (50mg). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Sitaglyn M Ir 50/1000 Tablet

Type 2 diabetes mellitus: to improve glycaemic control (blood sugar) along with diet and exercise; used when metformin alone is inadequate or as part of combination therapy.

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves HbA1c control
• Helps reduce hepatic glucose production and improves insulin sensitivity
• Lowers glucagon and increases glucose-dependent insulin release
• Convenient combination therapy to reduce pill burden

How Sitaglyn M Ir 50/1000 Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1/GIP), enhancing glucose-dependent insulin release and reducing glucagon. Metformin decreases hepatic glucose production and improves insulin sensitivity, lowering blood glucose without usually causing hypoglycaemia when used alone.

How to take Sitaglyn M Ir 50/1000 Tablet

Oral tablet. Take exactly as prescribed, usually with meals to reduce stomach upset. Swallow whole with water; do not crush/chew unless advised. Regularly monitor blood glucose; follow diet and exercise advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Sitaglyn M Ir 50/1000 Tablet

Most side effects of Sitaglyn M Ir 50/1000 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• upper respiratory tract infection
• nasopharyngitis

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Sitaglyn M Ir 50/1000 Tablet

Warnings and precautions

Prescription-only anti-diabetic. Risk of lactic acidosis with metformin—higher in kidney impairment, dehydration, severe infection, shock, liver disease, heavy alcohol use; stop and seek urgent care for rapid breathing, severe weakness, muscle pain, unusual sleepiness. Contraindicated in severe renal impairment; assess eGFR before start and periodically. Hold metformin before/at time of iodinated contrast procedures and restart after renal function is re-evaluated. Sitagliptin may rarely cause pancreatitis (severe persistent abdominal pain), severe joint pain, hypersensitivity reactions; use caution in history of pancreatitis. Hypoglycaemia risk increases if used with insulin or sulfonylureas. Use caution in elderly and in conditions causing hypoxia.

Do not take Sitaglyn M Ir 50/1000 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for type 1 diabetes or for diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate/acetazolamide), cimetidine and other drugs affecting renal tubular secretion, diuretics/ACE inhibitors/NSAIDs (may affect kidney function), insulin and sulfonylureas (increase hypoglycaemia risk), digoxin (sitagliptin may slightly increase levels)

How to store Sitaglyn M Ir 50/1000 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Sitaglyn M Ir 50/1000 Tablet

Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them. It can be taken with or without food, at the same time each day. Keep up your diet and activity — this medicine supports them.

Manufacturer and class

Manufacturer:

ZYDUS HEALTHCARE PHARMA

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide