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Prescription requiredSun PharmaPAIN ANALGESICS

Synaptol SR 450

Tolperisone (450mg)

₹408MRP ₹429In stock
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Delivery across India. Free above ₹999; ₹49 from ₹499, ₹99 below. Chennai express delivery is chargeable.

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Synaptol SR 450 is used for muscle relaxation.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Tolperisone (450mg)
Available variants: NA 10`S
Best price: ₹408
MRP: ₹429
Prescription: Required
Manufacturer: SUN PHARMA

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Synaptol SR 450

Synaptol SR 450 contains Tolperisone (450mg). It belongs to the Centrally acting muscle relaxant class of medicines.

Uses of Synaptol SR 450

Muscle relaxation

Key benefits

  • In Muscle relaxation SynAPTOL SR 450 Tablet is a muscle relaxant that works by causing the muscles to become less stiff which in turn reduces pain and discomfort. All together it helps in easy movement. SynAPTOL SR 450 Tablet can help you do your daily activities without any problem. Some studies have shown that SynAPTOL SR 450 Tablet if used as advised can cause less drowsiness. It is advisable to continue the medicine until your doctor advises you to stop.

How Synaptol SR 450 works

SynAPTOL SR 450 Tablet is a muscle relaxant. It works on the centres in the brain and spinal cord to relieve muscle stiffness or spasm without reduction in strength. This improves pain and movement of muscles.

How to take Synaptol SR 450

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. SynAPTOL SR 450 Tablet should be taken with or after food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of SynAPTOL SR 450 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause deep drowsiness, muscle weakness, a fall in blood pressure and slowed breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Synaptol SR 450

Most side effects of Synaptol SR are mild and settle as the body adjusts. Reported side effects include:

  • Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Synaptol SR 450

PregnancyPregnancy CONSULT YOUR DOCTOR
BreastfeedingBreast feeding CONSULT YOUR DOCTOR
AlcoholAlcohol SAFE
DrivingDriving UNSAFE
KidneyKidney CAUTION
LiverLiver CAUTION
Habit formingNo

Warnings and precautions

This medicine causes drowsiness. Do not drive or operate machinery until you know how it affects you. Use it for the short course your doctor has prescribed — these are not intended for long-term use. Do not stop a long course abruptly without asking your doctor.

Do not take Synaptol SR if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with myasthenia gravis or severe liver disease.

Interactions with other medicines

Alcohol, sleeping tablets, antihistamines and opioid painkillers all add to the drowsiness, sometimes dangerously.

How to store Synaptol SR 450

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Synaptol SR 450

SynAPTOL SR 450 Tablet provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system. Consider taking with or after food or a glass of milk to prevent upset stomach. SynAPTOL SR 450 Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. Inform your doctor if you are pregnant, planning to conceive or breastfeeding. Do not stop taking it suddenly without talking to your doctor if you've been on it for a long time.

Manufacturer and class

Manufacturer:
SUN PHARMA
Therapeutic class:
PAIN ANALGESICS
Drug class:
Centrally acting muscle relaxant
Chemical class:
Aminoketones

Substitutes for Synaptol SR 450

Medicines with the same active ingredient (Tolperisone (450mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Synaptol SR 450
Tolifast SR 450 mg TabletLUPIN LABtablet · 6`S₹35214% cheaper
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Synaptol SR 450 FAQs

What is Synaptol SR 450 used for?
Synaptol SR 450 is commonly used for Muscle relaxation. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Synaptol SR 450?
Synaptol SR 450 contains Tolperisone (450mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Synaptol SR 450?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Synaptol SR 450 work?
SynAPTOL SR 450 Tablet is a muscle relaxant.
Is Synaptol SR 450 a prescription medicine?
Yes. Synaptol SR 450 is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Synaptol SR 450?
The side effects reported most often with Synaptol SR are Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Synaptol SR 450 be taken during pregnancy?
Pregnancy CONSULT YOUR DOCTOR Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Synaptol SR.
Can I drink alcohol while taking Synaptol SR 450?
Alcohol SAFE
What if I miss a dose of Synaptol SR 450?
If you miss a dose of SynAPTOL SR 450 Tablet, take it as soon as possible.
Is Synaptol SR 450 habit forming?
No. Synaptol SR 450 is not known to be habit forming when taken as prescribed.
Is there a cheaper substitute for Synaptol SR 450?
Tolifast SR 450 mg Tablet has the same active ingredient and strength and is listed from ₹352 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Synaptol SR 450 cost on PingMeDoc Pharmacy?
Synaptol SR 450 starts at ₹408 (MRP ₹429) on PingMeDoc Pharmacy. Available in NA 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Synaptol SR 450?
Synaptol SR 450 is manufactured by SUN PHARMA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Synaptol SR 450 delivered?
Synaptol SR 450 is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Synaptol SR 450, Quick facts

Salt
Tolperisone (450mg)
Best price
₹408
MRP
₹429
Prescription
Required (Rx)
Brand
SUN PHARMA
Manufacturer
SUN PHARMA
Therapeutic class
PAIN ANALGESICS
Drug class
Centrally acting muscle relaxant
Chemical class
Aminoketones
Action class
Centrally Acting Skeletal Muscle Relaxants
Habit forming
No
Variants
NA 10`S
Delivery
Standard across India

References

The information on Synaptol SR 450 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Synaptol SR 450.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.