
Acetamide 250
Micro Labs - 10 S
Prescription required
Paracetamol (325mg) + Polmacoxib (2mg)
Tolfen is used for this medicine is used in the treatment of fever, headache, body ache, mild to moderate pain, pain, inflammation, arthritis and period pain.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Tolfen contains Paracetamol (325mg) + Polmacoxib (2mg). It belongs to the Para-aminophenol derivative and Non-steroidal anti-inflammatory drug class of medicines.
This medicine combines 2 active ingredients: Paracetamol and Polmacoxib. Paracetamol reduces fever and relieves pain by acting on the parts of the brain that regulate temperature and register pain. Polmacoxib blocks the chemicals your body makes at a site of injury or inflammation, which reduces pain, swelling and fever.
Use this medicine as your doctor has directed. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe and sometimes fatal liver damage, often with no symptoms at all for the first day. It can cause stomach bleeding, kidney failure, drowsiness and fits. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Tolfen are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended in pregnancy — it may harm the developing baby. Tell your doctor at once if you are or might be pregnant. |
|---|---|
| Breastfeeding | Use with caution while breastfeeding; watch the baby for any unusual symptoms. |
| Alcohol | Do not drink alcohol while taking this medicine. |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Never exceed the daily maximum printed on the pack. Paracetamol overdose damages the liver, and the damage can be silent for a day or two before it becomes serious. Check every other medicine you are taking. Paracetamol is in a very large number of cold, flu and pain combinations, and the doses add together. If you drink alcohol regularly, or have liver disease, ask your doctor what daily limit is safe for you. See a doctor if fever lasts more than three days, or pain more than five. Take it with or just after food, and for the shortest time that works. Stop and seek urgent care for black or tarry stools, vomiting blood, or severe stomach pain — this group can cause bleeding from the stomach. Long or high-dose use raises the risk of heart attack, stroke and kidney injury, particularly in older people and those already at risk. Avoid if you are dehydrated or have an illness with vomiting or loose motions — the kidneys are vulnerable then. Must be avoided in the last three months of pregnancy.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with severe liver disease, except under medical supervision. Not for people with an active stomach ulcer, severe kidney or heart failure, or asthma triggered by aspirin or anti-inflammatory painkillers. Not in the third trimester of pregnancy.
Regular alcohol use increases the risk of liver injury. Tell your doctor if you are on warfarin — regular high-dose paracetamol can affect it. Combining with a blood thinner or aspirin sharply raises the bleeding risk. Reduces the effect of blood pressure medicines and water tablets, and together with them can harm the kidneys. Never take two anti-inflammatory painkillers at the same time.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Take the lowest dose that works, and leave the stated gap between doses. Seek help immediately after a suspected overdose, even if you feel completely well — treatment works best when it is early. Use the lowest dose for the shortest period. If you need a painkiller regularly, see your doctor rather than continuing on your own. Paracetamol is the safer choice for simple fever and headache.
Medicines with the same active ingredient (Paracetamol (325mg) + Polmacoxib (2mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Tolfen |
|---|---|---|---|
| Hisaka-P TabletERIS LIFE SCIENCES PVT LTD | tablet · 10`S | ₹121 | 19% cheaper |
| Palocap-P TabletAJANTA PHARMA | tablet · 10`S | ₹121 | 19% cheaper |

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The information on Tolfen is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.