Glyxambi 10/5 mg
Boehringer Ingelheim India Pvt Ltd - 10 S
Prescription required
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Metformin (1000mg) + Linagliptin (2.5mg)
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Trajenta Duo 2.5/500 Tablet is used for type 2 diabetes mellitus: to improve glycaemic control in adults when diet and exercise alone are not enough; used when appropriate to treat with both linagliptin and metformin.
19 brands registered in Bangladesh with the same salt, strength and form.
Brand names differ between countries. Ask a pharmacist or your doctor in Bangladesh before switching. We don't sell or ship these brands. Source: Directorate General of Drug Administration, Bangladesh.
Trajenta Duo 2.5/500 Tablet contains Metformin (1000mg) + Linagliptin (2.5mg). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.
Linagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), leading to increased insulin release and reduced glucagon in a glucose-dependent manner. Metformin reduces hepatic glucose production and improves peripheral insulin sensitivity, lowering blood glucose.
Oral tablet. Take as prescribed, usually twice daily with meals to reduce stomach upset. Swallow whole with water; do not crush/chew. Maintain diet, exercise, and regular blood sugar monitoring.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Trajenta Duo 2.5mg/1000mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Trajenta Duo 2.5/500 are mild and settle as the body gets used to the medicine. The ones reported most often are:
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Risk of lactic acidosis with metformin (rare but serious): seek urgent care for rapid breathing, severe weakness, abdominal pain, drowsiness. Avoid/use caution in kidney impairment; assess eGFR before and during therapy (contraindicated in severe renal impairment). Temporarily stop metformin around iodinated contrast imaging and major surgery as advised. Use caution in liver disease, alcoholism, dehydration, severe infection, hypoxia/heart failure. Pancreatitis has been reported with DPP-4 inhibitors—stop and seek care if severe persistent abdominal pain. Monitor for hypersensitivity reactions and bullous pemphigoid symptoms.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for type 1 diabetes or for diabetic ketoacidosis.
Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cationic drugs affecting renal tubular secretion (e.g., cimetidine), insulin and sulfonylureas (increased hypoglycaemia risk), rifampicin and other strong P-gp/CYP3A4 inducers (may reduce linagliptin effect), corticosteroids and diuretics (may raise glucose), beta-blockers (may mask hypoglycaemia symptoms)
Store below 25°C, protect from moisture and light, keep in original blister pack, keep out of reach of children.
People taking Trajenta Duo 2.5/500 are often asked to check these from time to time. Your doctor decides which and how often.
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Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.