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Dr Reddys Laboratories Ltd - Tablet - 10 S
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Amitriptyline (75mg)
Tryptomer 75 Tablet is used for depression; neuropathic (nerve) pain; prevention of migraine/tension-type headache (as prescribed); certain anxiety/sleep disorders (off-label, doctor-directed).
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Tryptomer 75 Tablet contains Amitriptyline (75mg). It belongs to the Tricyclic antidepressant (TCA) class of medicines.
Amitriptyline is a tricyclic antidepressant that increases levels of serotonin and noradrenaline in the brain by inhibiting their reuptake, improving mood. It also modulates pain pathways and has sedative effects, which can help in neuropathic pain and sleep.
Take exactly as prescribed. Usually taken by mouth once daily, preferably at bedtime due to drowsiness; can be taken with or without food. Swallow whole with water. Do not stop suddenly—dose is usually tapered by the doctor.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Tryptomer 75mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Tryptomer are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Use with caution / Consult doctor (use only if benefit outweighs risk) |
|---|---|
| Breastfeeding | Breast feeding CONSULT YOUR DOCTOR |
| Alcohol | Avoid (can increase drowsiness, dizziness and impair coordination) |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver CAUTION |
| Habit forming | No |
May cause marked drowsiness—avoid driving/operating machinery until effects are known. Risk of suicidal thoughts/behavior especially at start of therapy or dose changes; monitor closely. Avoid in recent heart attack; use caution in heart disease, arrhythmias, glaucoma (narrow-angle), urinary retention/prostate enlargement, seizures, bipolar disorder/mania, liver disease, and elderly (higher anticholinergic effects/fall risk). Do not use with MAO inhibitors (or within 14 days). Serotonin syndrome risk with serotonergic medicines. Do not stop abruptly (withdrawal symptoms).
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one.
MAO inhibitors (contraindicated), other antidepressants/SSRIs/SNRIs (e.g., fluoxetine, sertraline) and triptans (serotonin syndrome risk), alcohol/CNS depressants (increased sedation), anticholinergics (increased side effects), QT-prolonging drugs (e.g., certain antiarrhythmics/antipsychotics/macrolides), antihypertensives (additive hypotension), cimetidine (increases levels), carbamazepine/phenytoin (may reduce levels), tramadol (seizure/serotonin syndrome risk), warfarin (may alter anticoagulant effect)
Store at room temperature (below 25°C), protected from light and moisture. Keep in original pack and out of reach of children.
Tryptomer 75mg Tablet may cause sleepiness. Take it at bedtime and do not drive or perform any activity requiring concentration until you know how it affects you. Avoid consuming alcohol while taking Tryptomer 75mg Tablet, as it may cause excessive sleepiness. Monitor your weight during treatment, as this medicine can cause weight gain and increased appetite. It may cause a sudden drop in blood pressure. Rise slowly if you have been sitting or lying down. Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behavior, thoughts, or feelings. This is particularly important when the medicine is started or when the dose is changed. This medication can significantly reduce saliva production, leading to dry mouth (xerostomia). Maintain strict oral hygiene by brushing twice daily with toothpaste and flossing regularly. This medication may reduce tear production, leading to dry eyes. If you wear contact lenses, your doctor may advise using preservative-free lubricating eye drops to maintain proper eye and lens hygiene.

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Prescription required
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The information on Tryptomer 75 Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.