Zomelis Met 50/500 Tablet

Composition of Zomelis Met 50/500 Tablet

Zomelis Met 50/500 Tablet contains Metformin (500mg) + Vildagliptin (50mg). It belongs to the DPP-4 inhibitor + Biguanide class of medicines.

Uses of Zomelis Met 50/500 Tablet

• Type 2 diabetes mellitus (to improve blood glucose control along with diet and exercise)
• especially in patients inadequately controlled on metformin alone or requiring sitagliptin + metformin combination

Key benefits

• Helps lower fasting and post-meal blood sugar
• Improves insulin response and reduces excess glucose production
• Lowers HbA1c when diet and exercise are insufficient
• Weight-neutral profile compared with some antidiabetics
• Convenient combination to reduce pill burden

How Zomelis Met 50/500 Tablet works

Sitagliptin is a DPP-4 inhibitor that increases incretin hormones, leading to increased insulin release and reduced glucagon secretion in a glucose-dependent manner. Metformin decreases hepatic glucose production and improves insulin sensitivity, reducing intestinal glucose absorption and lowering blood glucose levels.

How to take Zomelis Met 50/500 Tablet

Tablet; take exactly as prescribed. Usually taken with meals to reduce stomach upset; swallow whole with water (do not crush/chew unless advised). Dose and frequency depend on blood sugar control and kidney function.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Zomelis Met 50mg/500mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zomelis Met 50/500 Tablet

Most side effects of Zomelis Met 50/500 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• upper respiratory tract infection
• hypoglycaemia (especially with insulin/sulfonylureas)
• rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zomelis Met 50/500 Tablet

Warnings and precautions

Prescription (Schedule H) medicine. Risk of lactic acidosis with metformin—seek urgent care for fast breathing, severe weakness, muscle pain, unusual sleepiness, or abdominal discomfort; higher risk in kidney impairment, dehydration, severe infection, hypoxia, heavy alcohol use, and elderly. Monitor renal function before and during therapy; not recommended in severe renal impairment. Temporarily stop around iodinated contrast procedures and major surgery as advised. Sitagliptin may rarely cause pancreatitis—seek medical help for severe persistent abdominal pain. Use caution in heart failure history and in patients prone to hypoglycaemia when combined with insulin or sulfonylureas.

Do not take Zomelis Met 50/500 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for type 1 diabetes or for diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cimetidine, ranolazine, dolutegravir, vandetanib, drugs that raise blood glucose (corticosteroids, thiazide/loop diuretics), insulin and sulfonylureas (increased hypoglycaemia risk)

How to store Zomelis Met 50/500 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep in original strip and out of reach of children.

Expert advice for Zomelis Met 50/500 Tablet

Take it in addition to regular exercise and a healthy diet to lower levels of blood sugar. Take it with food to lower your chance of having an upset stomach. Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic. Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain, as Zomelis Met 50mg/500mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood. Your doctor may check your kidney and liver function before starting treatment and regularly thereafter. Inform your doctor if you develop symptoms such as abdominal pain, fatigue, loss of appetite, darkened urine, or yellowing of the eyes or skin (jaundice).

Manufacturer and class

Manufacturer:

ERIS LIFE SCIENCES PVT LTD

Therapeutic class:

Antidiabetic

Drug class:

DPP-4 inhibitor + Biguanide