Zoryl M 0.5 Tablet

Composition of Zoryl M 0.5 Tablet

Zoryl M 0.5 Tablet contains Glimepiride (0.5mg). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Zoryl M 0.5 Tablet

• Type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; helps control high blood sugar
• usually as add-on/combination therapy.

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin release and insulin sensitivity
• Helps reduce diabetes-related complications with long-term control
• Convenient dual-therapy in one tablet

How Zoryl M 0.5 Tablet works

Glimepiride (a sulfonylurea) stimulates the pancreas to release insulin and improves peripheral glucose utilization. Metformin (a biguanide) decreases glucose production in the liver and improves insulin sensitivity, lowering blood glucose without usually causing weight gain.

How to take Zoryl M 0.5 Tablet

Take by mouth as prescribed, usually once daily with the main meal (preferably breakfast) to reduce stomach upset and risk of low sugar. Swallow whole (do not crush/chew if prolonged-release). Monitor blood glucose regularly; do not stop abruptly without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Zoryl-M 2 Tablet PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zoryl M 0.5 Tablet

Most side effects of Zoryl M are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia (low blood sugar)
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• weight gain
• skin rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl M 0.5 Tablet

Warnings and precautions

Risk of hypoglycaemia (more with missed meals, alcohol, excessive exercise, kidney/liver impairment); carry a fast-acting glucose source. Metformin may rarely cause lactic acidosis—seek urgent help for rapid breathing, severe weakness, muscle pain, abdominal pain, or unusual sleepiness; higher risk with significant kidney disease, dehydration, severe infection, heart/respiratory failure. Avoid in severe renal impairment; dose adjustment/monitoring needed in kidney disease and elderly. Hold metformin around iodinated contrast procedures and major surgery as advised by doctor. Use caution in liver disease; monitor HbA1c and renal function periodically.

Do not take Zoryl M if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease.

Interactions with other medicines

Alcohol, insulin and other antidiabetics (additive hypoglycaemia), beta-blockers (may mask hypoglycaemia symptoms), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide/loop diuretics (may raise glucose), rifampicin (may reduce glimepiride effect), azole antifungals/macrolides/fluoroquinolones (may increase hypoglycaemia risk), NSAIDs and salicylates (may increase sulfonylurea effect), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (may increase metformin levels)

How to store Zoryl M 0.5 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

Expert advice for Zoryl M 0.5 Tablet

You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Zoryl-M 2 Tablet PR. Take it with food to lower your chance of having an upset stomach. Monitor your blood sugar level regularly while you are taking this medicine. It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic. Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Zoryl-M 2 Tablet PR may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide

Chemical class:

Benzenesulfonamides