Daparyl M 5/1000 Tablet

Composition of Daparyl M 5/1000 Tablet

Daparyl M 5/1000 Tablet contains Dapagliflozin 5 mg + Metformin Hydrochloride 1000 mg (usually extended-release). It belongs to the SGLT2 inhibitor + Biguanide class of medicines.

Uses of Daparyl M 5/1000 Tablet

Type 2 diabetes mellitus (as an adjunct to diet and exercise) to improve glycaemic control when dual therapy is appropriate or when patients are uncontrolled on metformin or an SGLT2 inhibitor alone

Key benefits

• Lowers HbA1c and fasting/postprandial glucose
• Helps weight reduction or weight neutrality
• Lowers risk of hypoglycaemia when used without insulin/sulfonylurea
• May provide cardiovascular and renal protective benefits associated with SGLT2 inhibitors

How Daparyl M 5/1000 Tablet works

Dapagliflozin is an SGLT2 inhibitor that lowers blood glucose by increasing urinary glucose excretion from the kidneys. Metformin reduces hepatic glucose production and improves insulin sensitivity, decreasing intestinal glucose absorption and improving peripheral glucose uptake.

How to take Daparyl M 5/1000 Tablet

Oral tablet. Take exactly as prescribed; commonly taken once daily with food (preferably with the evening meal if extended-release) to reduce stomach upset. Swallow whole; do not crush/chew if ER. Maintain adequate hydration; monitor blood glucose as advised.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Daparyl M 5/1000 as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Daparyl M 5/1000 than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Daparyl M 5/1000 Tablet

Most side effects of Daparyl M 5/1000 are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• diarrhoea
• abdominal discomfort
• loss of appetite
• genital fungal infection
• urinary tract infection
• increased urination
• thirst
• dizziness
• headache

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Daparyl M 5/1000 Tablet

Warnings and precautions

Not for type 1 diabetes. Risk of lactic acidosis with metformin (higher risk in kidney impairment, dehydration, severe infection, heavy alcohol use, liver disease, heart failure, hypoxia); seek urgent care for fast breathing, severe weakness, abdominal pain, drowsiness. Dapagliflozin may cause genital mycotic infections, UTIs, volume depletion/low BP, and rare ketoacidosis (can occur with near-normal sugars); stop and seek care if nausea/vomiting, abdominal pain, rapid breathing. Assess renal function before and during therapy; dose/continuation depends on eGFR and product label. Temporarily withhold during acute illness, prolonged fasting, major surgery, or dehydration. Hold metformin around iodinated contrast procedures as per clinician advice. Monitor for hypoglycaemia if used with insulin/sulfonylureas.

Interactions with other medicines

Alcohol (increases lactic acidosis risk),insulin and sulfonylureas (increased hypoglycaemia),diuretics/antihypertensives (enhanced dehydration/hypotension),iodinated contrast media (lactic acidosis risk—temporary stop),carbonic anhydrase inhibitors e.g. topiramate/acetazolamide (metabolic acidosis risk),cimetidine (may increase metformin levels),rifampicin (may alter dapagliflozin exposure),NSAIDs/ACE inhibitors/ARBs (renal function changes—monitor)

How to store Daparyl M 5/1000 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

SGLT2 inhibitor + Biguanide