Daparyl M 5/1000 Tab

Composition

Dapagliflozin 5 mg + Metformin Hydrochloride 1000 mg (usually extended-release)

Uses of Daparyl M 5/1000 Tab

Type 2 diabetes mellitus (as an adjunct to diet and exercise) to improve glycaemic control when dual therapy is appropriate or when patients are uncontrolled on metformin or an SGLT2 inhibitor alone

• •Lowers HbA1c and fasting/postprandial glucose
• •Helps weight reduction or weight neutrality
• •Lowers risk of hypoglycaemia when used without insulin/sulfonylurea
• •May provide cardiovascular and renal protective benefits associated with SGLT2 inhibitors

How it works

Dapagliflozin is an SGLT2 inhibitor that lowers blood glucose by increasing urinary glucose excretion from the kidneys. Metformin reduces hepatic glucose production and improves insulin sensitivity, decreasing intestinal glucose absorption and improving peripheral glucose uptake.

Directions for use

Oral tablet. Take exactly as prescribed; commonly taken once daily with food (preferably with the evening meal if extended-release) to reduce stomach upset. Swallow whole; do not crush/chew if ER. Maintain adequate hydration; monitor blood glucose as advised.

Side effects

Common side effects of Daparyl M 5/1000 Tab may include:

• •Nausea
• •diarrhoea
• •abdominal discomfort
• •