Gledepa Met 5/1000 mg

Composition of Gledepa Met 5/1000 mg

Gledepa Met 5/1000 mg contains Dapagliflozin 5 mg + Metformin 1000 mg (as Metformin Hydrochloride). It belongs to the SGLT2 inhibitor + Biguanide class of medicines.

Uses of Gledepa Met 5/1000 mg

• Treatment of type 2 diabetes mellitus in adults to improve glycaemic control (as an adjunct to diet and exercise)
• especially when control is inadequate with metformin or when combination therapy is appropriate.

Key benefits

• Lowers blood glucose in type 2 diabetes
• Improves insulin sensitivity and reduces liver glucose output
• Promotes urinary glucose excretion
• May aid modest weight reduction and BP lowering with dapagliflozin
• Convenient combination therapy to improve HbA1c

How Gledepa Met 5/1000 mg works

Dapagliflozin is an SGLT2 inhibitor that reduces glucose reabsorption in the kidneys, increasing urinary glucose excretion and lowering blood sugar. Metformin decreases hepatic glucose production and improves insulin sensitivity, reducing glucose absorption and improving peripheral glucose uptake.

How to take Gledepa Met 5/1000 mg

Oral tablet. Take exactly as prescribed, usually once or twice daily with meals to reduce stomach upset (metformin component). Swallow whole with water; do not crush/chew. Maintain adequate hydration; follow diet/exercise advice and monitor blood glucose as directed.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause dehydration and a fall in blood pressure. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Gledepa Met 5/1000 mg

Most side effects of Gledepa Met 5/1000 mg are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• vomiting
• diarrhoea
• abdominal discomfort
• loss of appetite
• genital fungal infections
• urinary tract infection
• increased urination
• thirst
• dizziness
• headache

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Gledepa Met 5/1000 mg

Warnings and precautions

Type 2 diabetes only (not for type 1 diabetes). Risk of lactic acidosis with metformin (higher risk in kidney impairment, dehydration, severe infection, hypoxia, excessive alcohol); stop and seek urgent care if rapid breathing, severe weakness, abdominal pain, or drowsiness occur. Dapagliflozin can cause genital mycotic infections, UTIs, volume depletion/low BP, and rarely diabetic ketoacidosis (may occur even with near-normal glucose); seek care for nausea/vomiting, abdominal pain, breathlessness. Assess kidney function before and during treatment; avoid/use with caution in renal impairment as per clinician. Temporarily withhold during major surgery, acute illness, prolonged fasting, or before iodinated contrast procedures per doctor advice. Monitor for hypoglycaemia if used with insulin/sulfonylureas.

Do not take Gledepa Met 5/1000 mg if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Insulin and sulfonylureas (increased hypoglycaemia risk), diuretics (increased dehydration/low BP risk), ACE inhibitors/ARBs and other antihypertensives (additive BP lowering), iodinated contrast media (increased lactic acidosis risk—hold metformin around procedure as advised), carbonic anhydrase inhibitors e.g. topiramate/acetazolamide (increased metabolic acidosis risk), alcohol (increases lactic acidosis risk), cationic drugs affecting renal tubular secretion e.g. cimetidine (may increase metformin levels)

How to store Gledepa Met 5/1000 mg

Store below 25°C, in a dry place, protected from light and moisture. Keep out of reach of children.

Expert advice for Gledepa Met 5/1000 mg

Take it in the morning so the extra urine does not disturb your sleep. Keep up your fluid intake and maintain genital hygiene. Tell any doctor treating you for an acute illness that you take this medicine. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

ABBOTT HEALTHCARE LIMITED

Therapeutic class:

Antidiabetic

Drug class:

SGLT2 inhibitor + Biguanide