Glycomet Trio 2 Tablet

Composition of Glycomet Trio 2 Tablet

Glycomet Trio 2 Tablet contains Glimepiride 2 mg + Metformin Hydrochloride (SR) 500 mg + Pioglitazone 15 mg. It belongs to the Sulfonylurea + Biguanide + Thiazolidinedione (PPAR-γ agonist) combination class of medicines.

Uses of Glycomet Trio 2 Tablet

Type 2 diabetes mellitus in adults when diet and exercise alone or dual therapy is inadequate; helps control blood sugar levels and improves glycaemic control.

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves insulin sensitivity and reduces insulin resistance
• Helps achieve better HbA1c control than dual therapy
• Convenient triple-drug regimen in one tablet
• May reduce diabetes-related complications by improving glycaemic control

How Glycomet Trio 2 Tablet works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas. Metformin reduces glucose production in the liver and improves insulin sensitivity. Pioglitazone (a thiazolidinedione) improves insulin sensitivity in muscle and fat by activating PPAR-γ, thereby reducing insulin resistance.

How to take Glycomet Trio 2 Tablet

Tablet (oral). Take exactly as prescribed by the doctor, usually once daily with/after the first main meal to reduce stomach upset and risk of low sugar. Swallow whole; do not crush/chew the SR tablet. Monitor blood glucose regularly and follow diet/exercise advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar and marked stomach upset. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Glycomet Trio 2 Tablet

Most side effects of Glycomet Trio are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• diarrhoea
• abdominal pain
• metallic taste
• headache
• dizziness
• weight gain
• oedema (swelling)
• increased appetite

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Glycomet Trio 2 Tablet

Warnings and precautions

Schedule H prescription medicine. Risk of hypoglycaemia (higher with missed meals, heavy exercise, alcohol); carry a sugar source. Metformin: rare risk of lactic acidosis—higher in kidney impairment, dehydration, severe infection, hypoxia; kidney function should be checked before and during therapy; stop temporarily around iodinated contrast/surgery as advised. Pioglitazone can cause fluid retention and may worsen heart failure; use is not recommended in symptomatic heart failure. Monitor liver enzymes; avoid if active liver disease. May cause weight gain and oedema; report shortness of breath or rapid weight gain. Use caution in elderly and those with kidney/liver problems.

Do not take Glycomet Trio if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for people with heart failure, active bladder cancer or unexplained blood in the urine.

Interactions with other medicines

Alcohol (increases hypoglycaemia/lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (may mask hypoglycaemia symptoms), corticosteroids/diuretics (may raise glucose), rifampicin (reduces pioglitazone levels), gemfibrozil (increases pioglitazone levels), iodinated contrast media (metformin—lactic acidosis risk), ACE inhibitors (may enhance glucose-lowering), NSAIDs/salicylates (may increase hypoglycaemia risk)

How to store Glycomet Trio 2 Tablet

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep in original blister pack and out of reach of children.

Expert advice for Glycomet Trio 2 Tablet

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them. Take it with the first mouthful of your meal so it can act on that meal. Expect some wind in the first weeks; it usually settles.

Manufacturer and class

Manufacturer:

USV LIMITED

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide + Thiazolidinedione (PPAR-γ agonist) combination